James Clyburn Research Center

Lopes-Virella Research Lab

Maria F. Lopes-Virella, M.D., Ph.D.

Maria Lopes-Virella, M.D., Ph.D.

Division of Endocrinology, Diabetes & Metabolic Diseases

For more than 20 years the Lopes-Virella lab has studied glycation/oxidation of lipoproteins, lipoprotein metabolism in diabetes, and the role of inflammation and autoimmune responses in human atherosclerosis. This research has involved pioneering work on the role of inflammation as well as of modified lipoproteins circulating as immune complexes in the development of complications in diabetes. They have developed assays in the laboratory for the analysis of modified LDL and their corresponding antibodies in isolated immune complexes. The assays and their clinical application have been awarded a patent. They have also dedicated considerable effort to the study of the biological characteristics of modified LDL immune complexes to further understand their possible pathological implications and their clinical value as biomarkers of cardiovascular disease and diabetes complications.


PubMed Collection