Dr. Gregory Cote

Cote Research Group

Gregory A. Cote, M.D., MS

Gregory Cote, M.D., MS

Division of Gastroenterology & Hepatology                                

Dr. Gregory Cote’s clinical research program focuses on outcomes research in pancreatobiliary diseases, including acute and chronic pancreatitis, pancreatic ductal adenocarcinoma and its precursors, bile duct strictures, and gallstone-related diseases. A principal focus of these studies includes outcomes research in pancreatobiliary endoscopy, including endoscopic ultrasound and 
endoscopic retrograde cholangio pancreatography (ERCP).

One major study (the SHARP Trial) is a clinical trial of endoscopic retrograde cholangiopancreatography with minor papilla sphincterotomy (a.k.a., minor papillotomy) for patients with two or more episodes of acute pancreatitis and pancreas divisum, which is an anatomic variant where the pancreatic duct drains through a separate opening from the bile duct. This study is being conducted at more than 15 centers in the U.S., U.K., Canada, and Netherlands with the support of an NIH cooperative agreement. To learn more about the SHARP Trial, please visit here . To visit the Clinical Trials study visit here.

A second important study is a longitudinal cohort of patients who undergo endoscopic retrograde cholangiopancreatography for idiopathic acute pancreatitis and sphincter of Oddi dysfunction (RESPOnD Study). The latter is a controversial medical condition believed to cause intermittent episodes of abdominal pain akin to “gallbladder spasms” or, less commonly, acute pancreatitis. Subjects enrolled in this study are being followed longitudinally to carefully measure the clinical impact of the endoscopic procedure.

Another important trial (PERCePT Trial) led by Dr. Cote that is underway is a single center pilot study funded by the Department of Defense that evaluates whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic pancreatitis with pancreatic duct obstruction. For more information please visit here


PubMed Collections

Senior Author Publications:

Senior Author PubMed Collection (senior author publications are most often associated with mentored projects)