Sirius Red staining showing red collagen fibrils in a liver section from mice with Fatty Liver Disease

Syn Clinical Research Lab

Wing Kin Syn, MBBS, Ph.D.

Wing-Kin Syn, M.D., Ph.D.

Professor
Division of Gastroenterology & Hepatology

Clinical / Translational Research: overarching goals are to improve the treatment and outcomes of patients with nonalcoholic fatty liver disease (NAFLD).

Through multiple cross-sectional and prospective studies, we hope to understand why only a proportion of patients will develop progressive liver disease, and hope to develop algorithms that identify at-risk subgroups. Some of our investigator-initiated research projects include: a) 'Use of weight loss medications to reduce cardiovascular risk in Veterans with NAFLD' aims to evaluate the benefits of VA approved weight loss medication on liver and cardiac outcomes (with Dr. Litwin, Cardiology). b) 'Prevalence and Risk factors for liver fibrosis in patients type 2 diabetes mellitus'. c) 'Role of the hedgehog pathway in accelerated liver fibrosis among individuals with HIV' (with Duke University). d) 'Develop models to identify individuals with NAFLD and Predict progression' (with Dr. Frey, Biomedical Informatics Center).

In addition, Dr. Syn is Site PI for multiple liver clinical trials. Specifically, patients with NAFLD will have the opportunity to participate in phase 2, 3, 4 NASH fibrosis and cirrhosis clinical trials at the Ralph H Johnson (Charleston) VA Medical Center (VAMC). The RHJ VAMC is only one of a handful of VAMCs that offers access to such trials within the Veterans Health Administration, and is nationally recognized as one of the top-tier NAFLD research sites.

Publications

PubMed Collection

Senior Author Publications:

Senior Author PubMed Collection (senior author publications are most often associated with mentored projects)