Publications

When worlds collide: Th17 and Treg cells in cancer and autoimmunity.
Knochelmann HM, Dwyer CJ, Bailey SR, Amaya SM, Elston DM, Mazza-McCrann JM, Paulos CM
Cellular & Molecular Immunology. 2018 May; 15(5):458-469. doi: 10.1038/s41423-018-0004-4.

In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Hu X, Majchrzak K, Liu X, Wyatt MM, Spooner CJ, Moisan J, Zou W, Carter LL, Paulos CM.
Cancer Research. 2018 Jul 15; 78(14):3888-3898. doi: 10.1158/0008-5472.CAN-17-3973.

CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Knochelmann HM, Smith AS, Dwyer CJ, Wyatt MM, Mehrotra S, Paulos CM.
Frontiers in Immunology. 2018 Jul 27; 9:1740. doi: 10.3389/fimmu.2018.01740. 

Human CD26highT cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence
Bailey SR, Nelson MH, Majchrzak K, Bowers JS, Wyatt MM, Smith AS, Neal LR, Shirai K, Carpenito C, June CH, Zilliox MJ, Paulos CM.
Nature Communications. 20.7;8(1):1961. doi: 10.1038/s41467-017-01867-9.

PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+T Cells 1000 Badge
Jacob S. Bowers,Kinga Majchrzak,Michelle H. Nelson,Bulent Arman Aksoy, Megan M. Wyatt,Aubrey S. Smith,Stefanie R. Bailey,Lillian R. Neal,Jeffrey E. HammerbacherandChrystal M. Paulos
Frontiers in Immunology. 2017;8:1221. doi: 10.3389/fimmu.2017.01221.

The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies
Lillian R. Neal, Stefanie R. Bailey, Megan M. Wyatt, Jacob S. Bowers, Kinga Majchrzak, Michelle H. Nelson, Carl Haupt, Chrystal M. Paulos and Juan C. Varela
Journal of Immunology Research and Therapy. 2017;2(1):68-80. 

β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity
Kinga Majchrzak, Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Megan M. Wyatt, John M. Wrangle, Mark P. Rubinstein, Juan C. Varela, Zihai Li, Richard A. Himes, Sherine S.L. Chan, Chrystal M. Paulos
JCI Insight. 2017;2(8):e90547. doi:10.1172/jci.insight.90547

Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.
Jacob S. Bowers, Michelle H. Nelson, Kinga Majchrzak, Stefanie R. Bailey, Baerbel Rohrer, Andrew D.M. Kaiser, Carl Atkinson, Luca Gattinoni, Chrystal M. Paulos
JCI Insight. 2017;2(5):e90772. doi:10.1172/jci.insight.90772

Synthetic RORg agonists regulate multiple pathways to enhance antitumor immunity
Xiao Hua, Xikui Liua, Jacques Moisana, Yahong Wanga, Charles A. Lescha, Chauncey Spoonera, Rodney W. Morgana, Elizabeth M. Zawidzkaa, David Mertza, Dick Bousleya, Kinga Majchrzakb, Ilona Kryczekc, Clarke Taylora, Chad Van Huisa, Don Skalitzkya, Alexander Hurda, Thomas D. Aichera, Peter L. Toogooda, Gary D. Glicka, Chrystal M. Paulosb, Weiping Zouc, and Laura L. Cartera
a Lycera Corp, Ann Arbor, MI, USA; b Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA; c University of Michigan, School of Medicine, Ann Arbor, MI, USA
Oncoimmunology. 2016 Nov 4;5(12):e1254854. doi: 10.1080/2162402X.2016.1254854.

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8+ T cells without host preconditioning
Michelle H. Nelson, Jacob S. Bowers, Stefanie R. Bailey, Marshall A. Diven, Caroline W. Fugle, Andrew D. M. Kaiser, Claudia Wrzesinski, Bei Liu, Nicholas P. Restifo and Chrystal M. Paulos
Journal for ImmunoTherapy of Cancer 2016 4:6 doi:10.1186/s40425-016-0110-8

Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic
Kinga Majchrzak, Michelle H. Nelson, Stefanie R. Bailey, Jacob S. Bowers, Xue-Zhong Yu, Mark P. Rubinstein, Richard A. Himes, Chrystal M. Paulos
Cancer Immunol Immunother (2016) 65: 247. doi:10.1007/s00262-016-1797-6

Harnessing the Microbiome to Enhance Cancer Immunotherapy
Michelle H. Nelson, Marshall A. Diven, Logan W. Huff, and Chrystal M. Paulos
Journal of Immunology Research. 2015;2015:368736. doi: 10.1155/2015/368736.  

Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling
Jacob S. Bowers, Michelle H. Nelson, Sreenath Kundimi, Stefanie R. Bailey, Logan W. Huff, Kristina M. Schwartz, David J. Cole, Mark P. Rubinstein and Chrystal M. Paulos
Clin Cancer Res June 1 2015 (21) (11) 2546-2557; doi: 10.1158/1078-0432.CCR-14-2294

The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue
Michelle H. Nelson, Sreenath Kundimi, Jacob S. Bowers, Carolyn E. Rogers, Logan W. Huff, Kristina M. Schwartz, Krishnamurthy Thyagarajan, Elizabeth C. Little, Shikhar Mehrotra, David J. Cole, Mark P. Rubinstein and Chrystal M. Paulos
J Immunol February 15, 2015,194(4)1737-1747; doi: 10.4049/jimmunol.1401082 

Novel immunotherapies for hematologic malignancies
Michelle H. Nelson, Chrystal M. Paulos
Immunological Reviews,Volume 263, Issue 1, January 2015, Pages 90–105, doi: 10.1111/imr.12245

Th17 cells in cancer: the ultimate identity crisis
Stefanie R. Bailey, Michelle H. Nelson, Richard A. Himes, Zihai Li, Shikhar Mehrotra, and Chrystal M. Paulos
Front. Immunol. 2014 Jun 17;5:276. doi: 10.3389/fimmu.2014.00276.

The Inducible Costimulator (ICOS) Is Critical for the Development of Human Th17 Cells
Chrystal M. Paulos1, Carmine Carpenito1, Gabriela Plesa1, Megan M. Suhoski2, Angel Varela-Rohena1, Tatiana N. Golovina1, Richard G. Carroll1, James L. Riley1and Carl H. June1
1 Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
2 Stanford University School of Medicine, Palo Alto, CA 94305–2296, USA.

Science Translational Medicine 27 Oct 2010:Vol. 2, Issue 55, pp. 55ra78; doi: 10.1126/scitranslmed.3000448