Li Lab Publications

2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 and Older


  • Wallace CH, Wu BX, Salem M, Ansa-Addo EA, Metelli A, Sun S, Gilkeson G, Shlomchik MJ, Liu B, Li Z. (2018) B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex. JCI Insight. doi: 10.1172/jci.insight.99863 [PubMed]
  • Metelli A, Salem M, Wallace CH, Wu BX, Li A, Li X, Li Z. (2018) Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer. J Hematol Oncol. doi: 10.1186/s13045-018-0570-z. Review [PubMed]
  • Wrangle JM, Patterson A, Johnson CB, Neitzke DJ, Mehrotra S, Denlinger CE, Paulos CM, Li Z, Cole DJ, Rubinstein MP. (2018) IL-2 and Beyond in Cancer Immunotherapy. J Interferon Cytokine Res. doi: 10.1089/jir.2017.0101 [PubMed]
  • Rachidi S, Wallace K, Li H, Lautenschlaeger T, Li Z. (2018) Postdiagnosis aspirin use and overall survival in patients with melanoma. J Am Acad Dermatol. doi: 10.1016/j.jaad.2017.12.076 [PubMed]


  • Kim DS, Song L, Wang J, Wu H, Gu G, Sugi Y, Li Z, Wang H. (2018) GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice. Endocrinology. doi: 10.1210/en.2017-00685 [PubMed]
  • Huck JD, Que NL, Hong F, Li Z, Gewirth DT. (2017) Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site. Cell Rep. doi: 10.1016/j.celrep.2017.08.079 [PubMed]
  • Wu BX, Li A, Lei L, Kaneko S, Wallace C, Li X, Li Z. (2017) Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis. J Biol Chem. doi: 10.1074/jbc.M117.797613 [PubMed]
  • Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA, Li Z. (2017) CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. doi: 10.1038/nsmb.3458. [PubMed]
  • Rachidi S, Metelli A, Riesenberg B, Wu BX, Nelson MH, Wallace C, Paulos CM, Rubinstein MP, Garrett-Mayer E, Hennig M, Bearden DW, Yang Y, Liu B and Li Z (2017) Platelets subvert T cell immunity against cancer via GARP-TGFbeta axis. Sci Immunol 2:eaai7911 (featured in the May 2017 cover) [PubMed]
  • Wang J, Yuan R, Song W, Sun J, Liu D, Li Z (2017) PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective. J Hematol Oncol 10(1):34. doi: 10.1186/s13045-017-0403-5. Review. [PubMed]
  • Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, Kimura Y, Hirano H, Ohara O, Udono H, Meng S, Liu B, Li Z (2017) Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS One 12(1):e0169260. doi: 10.1371/journal.pone.0169260 [PubMed]


  • Metelli, A., Wu, B., Fugle, C.W., Rachidi, S., Sun, S., Zhang, Y., Wu, J., Tomlinson, S., Howe, P., Garrett-Mayer, E., Liu, B., and Li, Z. (2016) Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer. Cancer Research. [PubMed]
  • Fugle, C.W., Zhang, Y., Hong, F., Sun, S., Westwater, C., Rachidi, S., Yu, H., Garret-Mayer, E., Kirkwood, K., Liu, B. and Li, Z., (2016) CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. OncoImmunology, [PubMed].
  • Ansa-Addo, E., Thaxton, J., Hong, F., Wu, B., Zhang, Y., Fugle, C.W., Metelli, A., Riesenberg, B., Williams, K., Gerwith, D., Chiosis, G., Liu, B., Li, Z. (2016). Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94. Current Topics in Medicinal Chemistry, 16(25), 2765–2778. [PubMed]
  • Liu, W., Chen, M., Li, X., Zhao, B., Hou, J., Zheng, H., Qiu, L., Li, Z. and Meng, S., (2016) Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response. PloS one, 11(5), p.e0155202. [PubMed]


  • Zhang, Y., Wu, B.X., Metelli, A., Thaxton, J.E., Hong, F., Rachidi, S., Ansa-Addo, E., Sun, S., Vasu, C., Yang, Y. and Liu, B., (2015) GP96 is a GARP chaperone and controls regulatory T cell functions. The Journal of clinical investigation, 125(2): 859-869. [PubMed]
  • Rachidi, S., Sun, S., Wu, B. X., Jones, E., Drake, R. R., Ogretmen, B., Cowart, A., Clarke, C., Hannun, Y., Chiosis, G., Liu, B., Li, Z. (2015). Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. Journal of Hepatology62(4), 879–888. [PubMed]
  • Zhang, Y., Ansa-Addo, E., & Li, Z. (2015). GP96: safeguarding Treg. Oncotarget, 6(24), 19936–19937. [PubMed]
  • Wu BX, Hong F, Zhang Y, Ansa-Addo E, Li Z. GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development. Adv Cancer Res. 129:165-90. [PubMed]
  • Rachidi, S., Wallace, K., Wrangle, J.M., Day, T.A., Alberg, A.J. and Li, Z., (2015). Neutrophil‐to‐lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma. Head & neck. Apr;38 Suppl 1:E1068-74 [PubMed]
  • Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z. (2015).Essential role of the molecular chaperone gp96 in regulating melanogenesis. Pigment Cell Melanoma Res. 27(1):82-9. [PubMed]


  • Thaxton, J. E., Liu, B., Zheng, P., Liu, Y., & Li, Z. (2014). Deletion of CD24 impairs development of heat shock protein gp96 -driven autoimmune disease through expansion of myeloid derived suppressor cells. Journal of Immunology. 192(12), 5679–5686. [PubMed]
  • Morales, C., Rachidi, S., Hong, F., Sun, S., Ouyang, X., Wallace, C., Zhang, Y., Garret-Mayer, E., Wu, J., Liu, B. and Li, Z., (2014) Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer research, 74(2): 446-459. [PubMed]
  • Hong, F., Wu, B. X., & Li, Z. (2014). Molecular regulation of macrophages in unleashing cancer-related inflammation. Oncoimmunology, 3, e27659. [PubMed]
  • Rachidi, S., Wallace, K., Day, T.A., Alberg, A.J. and Li, Z., (2014) Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. Journal of hematology & oncology, 27(7): 65. [PubMed]
  • Thaxton, J. E., & Li, Z. (2014). To affinity and beyond: Harnessing the T Cell receptor for cancer immunotherapy. Human Vaccines & Immunotherapeutics,10(11), 3313–3321. [PubMed]


  • Hua, Yunpeng, Shai White-Gilbertson, Joshua Kellner, Saleh Rachidi, Saad Z. Usmani, Gabriela Chiosis, Ronald DePinho, Zihai Li, and Bei Liu. "Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma." Clinical Cancer Research, 22 (2013): 6242-6251. [PubMed]
  • Hong, F., Liu, B., Chiosis, G., Gewirth, D.T. and Li, Z., (2013). α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96 A POTENTIAL THERAPEUTIC TARGET FOR CANCER METASTASIS. Journal of Biological Chemistry, 288(25): 18243-18248. [PubMed]
  • Rachidi, S.M., Qin, T., Sun, S., Zheng, W.J. and Li, Z., 2013. Molecular profiling of multiple human cancers defines an inflammatory cancer-associated molecular pattern and uncovers KPNA2 as a uniform poor prognostic cancer marker. PloS one, 8(3), p.e57911. [PubMed]
  • Liu, B., Staron, M., Hong, F., Wu, B.X., Sun, S., Morales, C., Crosson, C.E., Tomlinson, S., Kim, I., Wu, D. and Li, Z., (2013). Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway. Proceedings of the National Academy of Sciences, 110(17), pp.6877-6882. [PubMed]
  • Wu, Shuang, Feng Hong, Daniel Gewirth, Beichu Guo, Bei Liu, and Zihai Li. (2013). The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. Journal of Biological Chemistry 287(9): 6735-6742. [PubMed]


  • Liu, B., Staron, M., & Li, Z. (2012). Murine but Not Human Basophil Undergoes Cell-Specific Proteolysis of a Major Endoplasmic Reticulum Chaperone. PLoS ONE, 7(6), e39442. [PubMed]


  • Staron, M., Wu, S., Hong, F., Stojanovic, A., Du, X., Bona, R., Liu, B., Li, Z. (2011). Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood, 117(26), 7136–7144. [PubMed]
  • M Staron, Y Yang, B Liu, J Li, Y Shen, JC Zúñiga-Pflücker, HL Aguila, I Goldschneider and Li Z (2010) gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates the early T and B lymphopoiesis. Blood, 115(12):2380-90 [PubMed]
  • Han JM, Kwon NH, Lee JY, Jeong SJ, Jung HJ, Kim HR, Li Z, Kim S (2010) Identification of gp96 as a novel target for treatment of autoimmune disease in mice. PLoS One. 2010 Mar 23;5(3):e9792. [PubMed]
  • Liu, B., Yang, Y., Qiu, Z., Staron, M., Hong, F., Li, Y., Wu, S., Li, Y., Hao, B., Bona, R., Han, D., Li, Z. (2010). Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nature Communications1(6), 1–10. [PubMed]
  • Goldstein M and Li Z (2009) Roles of heat shock protein in inflammation-mediated tumorigenesis. J Hematol Oncol 2(5): 1-10. [PubMed]
  • Usmani S, Bona R and Li Z (2009) 17 AAG for Hsp90 inhibition in cancer – from bench to bedside. Curr Mol Med 9(5):654-64. [PubMed]
  • Dai J, Liu B and Li Z (2009) Toll-like receptors and regulatory T cells: what is the missing link? Int Immunopharmacol 9:528-533 [PubMed]
  • Morales C, Wu S, Yang Y, Hao B and Li Z (2009) Drosophila glycoprotein 93 is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for Toll-like receptors and integrins. J Immunol 183(8):5121-8 [PubMed]
  • Li Y, Zeng H, He R-H, Liu B and Li Z (2009) Vaccination with human embryonic stem cells generates a broad spectrum of clinical and immunological activities against colon cancer. Stem Cells 27(12):3103-11 [PubMed]
  • Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D (2008) Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. 118(1):195-204. [PubMed]
  • Qiao Y, Liu B and Li Z  (2008) Activation of human NK cells by HSP70 by the induction of NKG2D ligand on dendritic cells. Cancer Immunity8:12-19 [PubMed]
  • Liu B and Li Z (2008) Heat shock protein HSP90b1 (grp94, gp96) optimizes B cell function via chaperoning integrins and Toll-like receptors but not immunoglobulins. Blood 112(4):1223-30 [PubMed]
  • Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefrançois L and Li Z (2007) Heat shock protein gp96 is a master chaperone for Toll-like receptors and is important for the innate function of macrophages. Immunity 26(2):215-226 [PubMed]
  • Han JM, Park SG, Liu B, Park B-J, Kim JY, Jin CH, Song YW, Li Z and Kim S (2007) AIMP1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. Am J Pathol 170(6):2042-54. [PubMed]
  • Dai J, Liu B, Ngoi SM, Sun S, Vella AT and Li Z (2007) Toll-like receptor 4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells. J Immunol 178(5):3219-25. [PubMed]