- 15SFDRN24480016 (R. Adams) — 07/01/2015-06/30/2019
American Heart Association
Metabolic Determinants of Vascular Stiffness in Health Disparities Related Stroke
The major goals of this project is to understand why African Americans with multiple risk factors have poor stroke recovery compared to whites using animal models, mapping of human brain connections, and community based intervention.
- AARGD-16-440893 (C. Robinson) — 10/1/2016-09/30/2019
Obesity-related Cognitive Impairment: The Role of Brain Insulin
Due to the funding of 1R01NS099595-01A1, the major goals of this project have been changed to determine the role of hyperinsulinemia on insulin receptor signaling in primary brain vascular endothelial cells and human brain vascular endothelial cells.
- 1R01NS099595-01A1 (C. Robinson) — 12/01/2017-11/30/2022
Molecular Mechanisms Underlying Obesity-related Memory Deficits
The major goal of this project is to understand the molecular mechanisms underlying central nervous system insulin transport.
- *P20, COBRE (S. Kautz) — 04/01/2019-03
NIH/NIGMS P20 GM109040
South Carolina Research Center for Recovery from Stroke
Junior Investigator Project entitled: Effect of Insulin on Neuroplasticity and Cognitive Rehabilitation
The major goal of this study is to examine the therapeutic impact of intranasal insulin on recovery in a co-morbid mouse model of ischemic stroke.
- Clark DG, Boan AD, Sims-Robinson C, Adams RJ, Amella EJ, Benitez A, Lackland DT, Ovbiagele B. Differential impact of index stroke on dementia risk in African Americans compared to whites. Journal of Stroke and Cerebrovascular Diseases, 2018. 27(10):2725-2730.
- Hinder LM, O’Brien PD, Hayes JM, Backus C, Solway AP, Sims-Robinson C, Feldman EL. Dietary reversal of neuropathy in a murine model of prediabetes and the metabolic syndrome. Disease Models and Mechanisms, 2017. 10(6):717-725. PMCID: PMC5483005
- Sims-Robinson C, Bakeman A, Bruno E, Jackson S, Glasser R, Murphy GG, Feldman EL. Dietary reversal ameliorates short- and long-term memory deficits induced by high-fat diet early in life. PLoS One, 2016. 11(9):e0613883. PMCID: PMC5038939
- Sims-Robinson C, Bakeman A, Glasser R, Boggs J, Pacut C, Feldman EL. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Experimental Neurology 2016 277:261-7. PMCID: PMC4802497
- Sims-Robinson C, Bakeman A, Rosko A, Glasser R, Feldman EL. The role of oxidized cholesterol in diabetes-induced lysosomal dysfunction in the brain. Molecular Neurobiology, 2015 53(4):2287-96. PMCID: PMC4644712
- Sims-Robinson C, Hur J, Hayes JM, Dauch JR, Keller PJ, Brooks SV, Feldman EL. The role of oxidative stress in nervous system aging. PLoS One, 2013 8(7):e68011. PMCID: PMC3699525
- Sims-Robinson C*, Zhao S*, Hur J, Feldman EL. Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes. Diabetologia, 2012 55(8):2276-84. *Equally contributing author. PMCID: PMC3391332
- Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V. Selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus. PLoS One, 7, e31073, Epub, 2012. PMCID: PMC3280283
- Larkin LM, Davis C, Sims-Robinson C, Kostrominova T, VanRemmen H, Richardson A, Feldman EL, Brooks S. Skeletal muscle weakness due to deficiency of Cu,Zn superoxide dismutase is associated with loss of functional innervations. American Journal of Physiology-Regulatory, Integrative, and Comparative Physiology, 30, R1400-R1407, 2011. PMCID: PMC3213934
- Sims-Robinson C, Kim B, Rosko A, Feldman EL. How does diabetes accelerate Alzheimer disease pathology? Nature Reviews Neurology, 6, 551-559, 2010. PMCID: PMC3199576
- Oh SS, Hayes JM, Sims-Robinson C, Sullivan KA, Feldman EL. The effects of anesthesia on measures of nerve conduction velocity in male C57BL6/J mice. Neuroscience Letters, 483, 127-131, 2010. PMCID: PMC2941214
- Kochlamazashvili G*, Senkov O*, Grebenyuk S#, Robinson C#, Xiao MF, Stummeyer K, Gerardy-Schahn R, Engel AK, Feig L, Semyanov A, Suppiramaniam V, M. Schachner M, Dityatev A. Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors. Journal of Neuroscience, 30, 4171-4183, 2010. *#Equally contributing authors.
- Kanju PM, Parameshwaran K, Sims C, Bahr BA, Shonesy BC, Suppiramaniam V. Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Experimental Neurology, 214, 55-61, 2008.
- Parameshwaran K, Sims C, Kanju P, Vaithianathan T, Shonesy BC, Dhanasekaran M, Bahr BA. Amyloid beta peptide Aβ 1-42 but not Aβ 1-40 attenuates synaptic AMPA receptor function. Synapse, 61, 367-74, 2007.
- Kanju PM, Parameshwaran K, Vaithianathan T, Sims C, Huggins K, Bendiske J, Ryzhikov S, Bahr BA, Suppiramaniam V. Lysosomal dysfunction produces distinct alterations in synaptic AMPA and NMDA currents in hippocampus. Journal of Neuropathology and Experimental Neurology, 66, 779-788, 2007.
- Hammond MS*, Sims C*, Parameshwaran K, Suppiramaniam V, Schachner M, Dityatev A. Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death. Journal of Biological Chemistry, 281, 34859-34869, 2006. *Equally contributing author. **Editors pick as newsworthy article, commentary in Functional Glycomics Gateway, November, 2006 by Mirko von Elstermann.
Sims-Robinson C, Kim B, Feldman EL. “Diabetes and Cognitive Dysfunction. In: Zigmond MJ, Rowland LP, Coyle JT, eds. Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Academic Press, 189-201, 2015