Ledo Laboratory

an open laptop screen displaying graphed data

The focus of our research is on the emerging roles of brain neuro-immune interactions in synaptic plasticity, memory and Alzheimer’s Disease (AD). Our research program goal is to define the molecular mechanisms by which neuro-immune interactions modulate cognition in health and in disease bridging innovative multidisciplinary approaches, thus enabling our researchers to cross boundaries between disciplines and gain unique insights into relevant biological questions.

Our lines of research incorporate a broad array of experimental approaches, such as biochemistry, transcriptomics (single-nuclei, single-cell, ribosome profiling and bulk RNA sequencing), FACS, opto/chemogenetics, iDISCO, mouse genetics and behavioral neuroscience. In vivo calcium recording/imaging in freely behaving mice, in vivo multiphoton imaging, and circuit neuroscience.

Laboratory Website