Bobby Thomas, Ph.D.

Professor of PediatricsHeadshot of Dr. Thomas

Medical University of South Carolina
Children’s Research Institute
173 Ashley Avenue, Room 510
Charleston, SC, 29425

Email: thomasbo@musc.edu

Education & Training:
St. Berchman’s College, India, 1994, B.S. in Zoology
Banaras Hindu University, India, 1996, M.S. in Zoology
Indian Institute of Chemical Biology, India, 2002, Ph.D. in Neuroscience
Johns Hopkins University, USA 2005, Postdoctoral Fellow in Parkinson’s Disease

Research Interests:

The Thomas laboratory is focused on understanding the molecular mechanisms involved in the pathogenesis of both age-related and childhood neurodegenerative disorders, with special emphasis on mitochondrial dysfunction and stress signaling cascades involving oxidative stress and neuroinflammation. The overall goal is to utilize this mechanistic knowledge to develop tangible neuroprotective therapies.

 

Highlight Publications:

  • Thomas B., Muralikrishnan D., Mohanakumar K. P. In vivo hydroxyl radical generation in the striatum following systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res. 852: 221-224 (2000) PMID: 10661517.
  • Mohanakumar K. P., Muralikrishnan D., Thomas B. Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 864: 281-290, (2000) PMID: 10802035.
  • Thomas B., Mohanakumar K. P. Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the mouse nigrostriatum. J Pineal Res. 36: 25-32 (2004) PMID: 14675127.
  • Chung K. K. K., Thomas B., Li X., Pletnikova O., Troncoso J. C., Marsh L., Dawson V. L., Dawson T. M. S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function.  Science 304:1328-1331 (2004) PMID: 15105460.
  • von Coelln R., Thomas B., Savitt J. M., Lim K. L., Sasaki M., Hess E. J., Dawson V. L., Dawson T. M. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc. Natl. Acad. Sci. USA. 101: 10744-10749 (2004) PMID: 15249681.
  • *von Coelln R., *Thomas B., Andrabi S. A., Lim K. L., Savitt J. M., Saffary R., Andrabi S. A., Stirling W., Bruno K., Hess E. J., Lee M. K., Dawson V. L., Dawson T. M. Inclusion body formation and neurodegeneration are parkin independent in a mouse model of a- synucleinopathy. J Neurosci. 26:3685-3695 (2006) PMID: 16597723 *Equal contribution (Co-first authors of the article).
  • Thomas B., von Coelln R., Mandir A.S., Trinkaus D.L., Farah M., Lim K. L., Beal M.F., Dawson V. L., Dawson T. M. MPTP and DSP-4 susceptibility of substanta nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity. Neurobiol. Dis. 26: 312-322 (2007) PMID: 17336077.
  • Thomas B., Saravanan K.S., Mohanakumar K.P. In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole. Neurochem Intl. 52: 990-1001 (2008) PMID: 18164516.
  • Thomas B., Banerjee R., Starkova N., Zhang S., Calingasan N. Y., Yang L., Beal M. F., Starkov A. A. Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP model of Parkinson’s disease. Antioxid Redox Signal. 16(9):855-68 (2012) PMCID: PMC3292750.
  • Ammal Kaidery N., Banerjee R., Yang L., Smirnova N.A., Huspulian D.M., Liby K.T., Williams C.W., Yamamoto M., Kensler T.W., Ratan R., Sporn M.B., Beal F., Gazaryan I.G., Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson’s disease. Antioxid. Redox Signal. 18(2): 139-57. (2013) PMID: 22746536. PMCID: PMC3514006.
  • Ahuja M., Ammal Kaidery N., Yang L., Calingasan N., Smirnova N., Gaisin A., Gaisina I., Gazaryan I., Hushpulian D.M., Kaddour-Djebbar I., Bollag W.B., Morgan J.C., Ratan R.R., Starkov A., Beal M.F., Thomas B. Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced experimental Parkinson’s-like disease. J Neurosci. 36: 6332-6351 (2016). PMID: 27277809.
  • Kaidery N.A., Ahuja M., Thomas B. Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson’s disease. Mol Cell Neurosci. 103413. doi: 10.1016/j.mcn.2019.103413. (2019) PMID: 31644952.

Complete NCBI list: https://www.ncbi.nlm.nih.gov/myncbi/bobby.thomas.1/bibliography/public/