Bruce Hollis, Ph.D.

Professor of PediatricsHeadshot of Dr. Hollis

Medical University of South Carolina
Darby Children’s Research Institute
171 Ashley Avenue
Charleston, SC, 29425


Education & Training:

The Ohio State University, 1973, BS
The Ohio State University, 1976, MS
University of Guelph, Ontario, 1979, Ph.D.

Research Interests:

My laboratory has focused on the measurement of vitamin D and its metabolites in biological fluids. We have also played a pivotal role in the development of assays to measure vitamin D and these metabolites.  There methods were used over the last four decades to conduct hundreds of studies and trials. Our assays for 25(OH)D and 1,25(OH)2D were the first ones to be cleared for clinical diagnosis work by the FDA in the late 1990’s. These tools we used to achieve our primary goals of determining vitamin D mode of action in human health including calcium homeostasis, pregnancy, lactation and oncology which all continue into the present day. My laboratory was also the first to be awarded an IND by the FDA to conduct studies with elevated levels of vitamin D.  This IND remains in effect and has been accessed by many investigators to conduct their own studies.  

Highlight Publications:

  • Hollis B.W., D. Johnson, T.C. Hulsey, M. Ebeling, and C.L. Wagner, (2011), Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness, J Bone Miner Res., 26: 2341-2357, PMID: 21706518
  • Hollis B.W., C.L.Wagner, C.R.Howard, M. Ebeling, J.R. Shary, P.G.Smith, S.N, Taylor, K. Morella, R.A. Lawerence, and T.C. Hulsey (2015), Maternal versus infant vitamin D supplementation during lactation: a randomized controlled trial, Pediatrics, 136: 625-634, PMID 26416936
  • Rostami M., F.R. Tehrani, M. Simbar, R. Bidhendi Yarandi, S. Minooee, B.W. Hollis, and F.        Hosseinpanah (2018), Effectiveness of prenatal vitamin D screening and treatment program: a randomized field trial, J Clin Endocrinol Metabolism., 103: 2936-2948. PMID: 29788364
  • Ng, K., H.S. Nimeiri, N.J. McCleary, T.A. Abrams, M.B. Yurgelum, J.M Cleary, D.A. Rubinsun, D., Schrag, R. Miksad, A.J. Bullock, J. Allen, D. Zuckerman, E.Chan, J.A. Chan, B.M. Wolpin, M., Constantine, D.J. Weckstein, M.A. Faggen, C.A. Thomas, C. Kournioti, C.Yuan, C. Ganser, B. Wilkinson, C. Mackintosh, H. Zheng, B.W. Hollis, J.A. Meyerhardt, and C.S. Fuchs, (2019), Effect of high-dose vs standard dose vitamin D supplementation on progression-free survival among patients with advanced or metastatic colorectal cancer: The SUNSHINE randomized clinical trial. JAMA, 321: 1370-1379, PMID 30964527

Complete NCBI list: