Dieter Haemmerich, Ph.D., DSc

Professor of Pediatric CardiologyHeadshot of Dr. Dieter Haemmerich

Medical University of South Carolina
Darby Children’s Research Institute, Room 611
171 Ashley Avenue
Charleston, SC 29425

Email: haemmer@musc.edu

Education & Training:
Vienna University of Technology, Austria, 1998, M.S. in Electrical & Comp. Eng.
University of Wisconsin, Madison, 2000, M.S. in Biomedical Eng.
University of Wisconsin, Madison, 2001, Ph.D. in Biomedical Eng.
Vienna University of Technology, Austria, 2003, Dr. Sci. in Electrical & Comp. Eng.

Research Interests:
I am a bioengineer with expertise in the research on image-guided therapies for cancer and cardiac arrhythmia treatment. Specifically, my areas of expertise include: image-guided interventions; heat-activated drug delivery; computational modeling (thermal therapies; drug delivery); thermal tumor ablation (radiofrequency ablation; microwave ablation; focused ultrasound); cardiac catheter ablation (radiofrequency ablation; cryo ablation); tissue characterization (dielectric and thermal tissue properties). Related to these fields, I have expertise in ex vivo tissue studies, in vivo studies (rodents and large animals, including porcine and canine models) of thermal therapies and liposomal drug delivery, in development of novel therapeutic devices and experimental instrumentation, in vivo imaging and image processing, and computational modeling.

Highlight Publications:

  • Rossmann C, McCrackin MA, Armeson KE, Haemmerich D (2017), Temperature sensitive liposomes combined with thermal ablation: Effects of duration and timing of heating in mathematical models and in vivo., PLoS One, 12(6):e0179131, PMID: 28604815

  • Morley GE, Bernstein SA, Kuznekoff L, Saul JP, Haemmerich D (2019), “Permanent and transient electrophysiological effects during cardiac cryoablation documented by optical activation mapping and thermal imaging”, IEEE Trans Biomed Eng, 66:1844-51, PMID: 30418875

  • Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D (2018), Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes, Drug Delivery, 25:973-84, PMID: 29688083

  • Haemmerich D and Motamarry A (2018), Thermosensitive Liposomes for Image-Guided drug Delivery, Adv Cancer Res, 139:121-46, PMID: 29941102

  • Motamarry A, Negussie AH, Rossmann C, Small J, Wolfe AM, Wood BJ, Haemmerich D (2018), Real-time fluorescence imaging for visualization and drug uptake prediction during drug delivery by thermosensitive liposomes”, Int J Hyperthermia, 36:817-826, PMID: 31451077

  • Gasselhuber A, Dreher MR, Rattay F, Wood BJ, Haemmerich D (2012), Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model, PLoS ONE, 7:e47453, 2012, PMID: 23082168

  • Haemmerich D, Schutt DJ (2011), Radiofrequency ablation at low frequencies for targeted tumor heating: in-vitro and computational modeling results, IEEE Trans Biomed Eng, 58:404-410, PMID: 20934940

  • Gasselhuber A, Dreher MR, Negussie A, Wood BJ, Rattay F, Haemmerich D (2010), Mathematical spatio-temporal model of drug delivery from low-temperature sensitive liposomes during radiofrequency tumor ablation, Int J Hyperthermia, 26:499-513, PMID: 20377363

  • Haemmerich D, Lee Jr FT, Schutt DJ, Sampson LA, Webster JG, Mahvi DM (2005), Large-volume radiofrequency ablation of Ex Vivo bovine liver with multiple cooled cluster electrodes,  Radiology, 234:563-568, PMID: 15601891

  • Haemmerich D, Staelin ST, Tungjitkusolmun Tsai J-Z, Webster JG, Mahvi DM (2003), “In Vivo electrical conductivity of hepatic tumours.  Physiol Meas 24:251-260, PMID: 12812412

  • Haemmerich D, Tungjitkusolmun S, Staelin ST, Lee Jr FT, Mahvi DM, Webster JG (2002), Finite element analysis of hepatic multiple probe radio-frequency ablation,  IEEE Trans Biomed Eng 49:836-842, PMID: 12148822

Highlight Patents:

  • Haemmerich D., Mahvi D.M., Webster J.G., Schutt D.J., “Electrode Array for Tissue Ablation”,Pat.Nr. 7,367,974; 2008. Patent also granted in Germany (Pat.Nr. 602005045008.4), France (Pat.Nr. 1793756) and Italy (Pat.Nr. 1793756).Patent is licensed exclusively to Medical Engineering Innovations Inc., with an FDA 510(k) submission for a clinical device pending.
  • Lee Jr. F.T., Haemmerich D., Webster J.G., Wright A.S., Johnson C.D., Mahvi D.M., “Radio-frequency ablation system using multiple electrodes”, Pat.Nr. 8,486,065: 2013. Patent also granted in Japan (Pat.Nr. 4303590: 2010) Patent licensed exclusively to Medtronic. Device is commercially available and in clinical use since 2004.

Complete List of Published Work in pubmed (google scholar h-index: 43): https://scholar.google.com/citations?user=u4Eb_7MAAAAJ&hl=en