Shikhar Mehrotra PhD Grant STTR Grant

Drs. Mehrotra and Ogretmen

Shikhar Mehrotra, Ph.D., received a Small Business Technology Transfer (STTR) entitled Programming Metabolically Fit TILs for Immunotherapy with Lipo-Immuno Tech, LLC/NIH. The award is a collaboration between Dr. Mehrotra and Besim Ogretmen, Ph.D. CEO of Lip-Immuno Tech.

To establish and develop their approach for commercialization their proposed research will determine if human melanoma tumor-derived TILs could be ex vivo programmed to potent anti-tumor hybrid T1/17 phenotype. They will further establish if hybrid TILs are superior to conventional TILs in controlling melanoma tumor growth in vivo.

The belief is that this research will help adopt the novel ex vivo programming conditions for generating robust anti-tumor TILs that could be used in future adoptive T-cell immunotherapy clinical trials.