Otis Laboratory Publications

Vollmer KM*, Green LM*, Grant RI, Winston K.T., Doncheck EM, Bowen CW, Paniccia JE, Clarke RE, Siegler PN, Bordieanu B, Siemsen BM, Denton AR, Jhou TC, Rinker JA, McGinty, JF, Scofield MD, and Otis JM (in press, Nature Communications. An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice (*authors contributed equally).

Paniccia JE, Otis JM, and Scofield MD (2022). Looking to the stars for answers: strategies for determining how astrocytes influence neuronal activity. Computational and Structural Biotechnology 20: 4146-4156.

Siemsen BM, Barry SM, Vollmer KM, Green LM, Brock AG, Westphal AM, King RA, DeVries DM, Otis JM, Cowan CW, and Scofield MD (2022). A subset of nucleus accumbens neurons receiving dense and functional prelimbic cortical input are required for cocaine seeking. Frontiers in Cellular Neuroscience. 16: 844243

Grant RI, Doncheck EM, Vollmer KM, Winston KT, Romanova EV, Siegler PN, Bowen CW, and Otis JM (2021). Specialized coding patterns among dorsomedial prefrontal neuronal ensembles predict conditioned reward seeking. eLife 10: e65764.

Vollmer KM* Doncheck EM*, Grant RI, Winston KT, Romanova EV, Bowen CW, Siegler PN, Green LM, Bobadilla AC, Trujillo-Pisanty I, Kalivas PW, and Otis JM (2021). A novel assay allowing drug self-administration, extinction, and reinstatement testing in head-restrained mice. Frontiers in Behavioral Neuroscience. 15: 744715. PMCID: 8585999. (*authors contributed equally).

McGinty JF and Otis JM. (2020). Heterogeneity in the paraventricular thalamus: the traffic light of motivated behaviors. Frontiers in Behavioral Neuroscience 14: 590528.

Rodriguez-Romaguera J, Ung RL, Nomura H, Otis JM, Basiri ML, Namboodiri VMK, Zhu X, Robinson JE, van den Munkhof HE, McHenry JA, Eckman LEH, Kosyk O, Jhou TC, Kash TL, Bruchas MR, and Stuber GD. (2020). Prepronociceptin-expressing neurons in the extended amygdala encode and promote rapid arousal responses to motivationally salient stimuli. Cell Reports 33: 108362.

Resendez SL, Namboodiri VMK, Otis JM, Eckman LEH, Rodriguez-Romaguera J, Ung RL, Basiri ML, Kosyk O, Rossi MA, Dichter GS, and Stuber GD (2020). Social stimuli induce activation of oxytocin neurons within the paraventricular nucleus of the hypothalamus to promote social behavior in male mice. Journal of Neuroscience 40: 2282-2295.

Guo J, Otis JM, Suciu SK, Catalano C, Xing L, Constable S, Wachten D, Gupton S, Lee J, Lee A, Blackley KH, Ptacek T, Simon JM, Schurmans S, Stuber GD, Caspary T, and Anton ES. (2019). Primary cilia signaling promotes axonal tract development and is disrupted in Joubert syndrome-related disorders models. Developmental Cell 51: 759-774.

Parker KE*, Pedersen CE*, Gomez AM*, Spangler SM, Walicki MC, Feng SY, Stewart SL, Otis JM, Al-Hasani R, McCall JG, Sakers K, Bhatti DL, Copits BA, Gereau RW, Jhou T, Dougherty JD, Stuber GD, and Bruchas MR (2019). A paranigral nociceptin circuit that constrains motivation for reward. Cell 178: 653-671.

Rossi MA*, Basiri ML*, McHenry JA, Kosyk O, Otis JM, van den Munkhof HE, Bryois J, Hubel C, Breen G, Guo W, Bulik CM, Sullivan PF, and Stuber GD (2019). Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. Science 28: 1271-1274.O

tis JM*, Zhu M*, Namboodiri VMK, Cook CA, Kosyk O, Matan AM, Ying R, Hashikawa K, Trujillo-Pisanty I, Guo J, Ung RL, Rodriguez-Romaguera J, Anton ES, and Stuber GD (2019). Paraventricular thalamus projection neurons integrate cortical and hypothalamic signals for cue-reward processing. Neuron 103: 423-431.N

amboodiri VMK*, Otis JM*, van Heeswijk K, Voets ES, Alghorazi RA, Rodriguez-Romaguera J, Mihalas S, and Stuber GD (2019). Subpopulations of orbitofrontal neurons acquire and maintain a long-term cue-reward memory to guide behavioral adaptation. Nature Neuroscience 22: 1110-1121.

Otis JM, Fitzgerald MK, Yousuf H, Burkard J, Drake M, and Mueller D (2018). Prefrontal neuronal excitability maintains a cocaine-associated memory during retrieval. Frontiers in Behavioral Neuroscience 12: 119.  Otis JM, and Mueller D (2017). Reversal of cocaine-associated synaptic plasticity in prefrontal cortex parallels elimination of memory retrieval. Neuropsychopharmacology 42: 2000-2010.

Otis JM*, Namboodiri VMK*, Matan AM, Voets ES, Mohorn EP, Kosyk O, McHenry JA, Robinson JE, Resendez SL, Rossi MA, and Stuber GD (2017) Prefrontal cortex output circuits guide reward seeking through divergent cue encoding. Nature 543: 103-107. **Faculty of 1000, ranked ‘Exceptional’.

McHenry JA, Otis JM, Rossi MA, Robinson JE, Kosyk O, Miller NW, McElligott ZA, Budygin EA, Rubinow DR, and Stuber GD (2017). Dissection of a medial preoptic reward circuit that motivates social approach. Nature Neuroscience 20: 449-458. **Faculty of 1000, ranked ‘Very Good’. 

Guo J, Otis JM, Higginbotham H, Monckton, C, Cheng, J, Asokan, A, Mykytyn, K, Caspary T, Stuber GD, and Anton ES (2017). Primary cilia signaling drives the development of interneuronal connectivity. Developmental Cell 42: 286-300. 

Hutton SR, Otis JM, Kim S, Lamsal Y, Stuber GD, and Snider WD (2017). ERK/MAPK signaling is required for pathway-specific striatal motor functions. Journal of Neuroscience 23: 8102-8115.

Resendez SL, Jennings JH, Ung RL, Namboodiri VMK, Zhou ZC, Otis JM, Nomura H, McHenry JA, Kosyk O, and Stuber GD (2016). Visualization of cortical, subcortical and deep brain neural circuit dynamics during naturalistic behavior with head-mounted microscopes and chronically implanted lenses. Nature Protocols 11: 566-597.

Fitzgerald MK, Otis JM, and Mueller D (2016).  Distinct roles for β1 and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory. Behavioral Brain Research 296: 94-99.Otis JM, Werner CT, and Mueller D (2015). Noradrenergic regulation of fear and drug-associated memory reconsolidation.  Neuropsychopharmacology 40: 793-803.

Otis JM, Fitzgerald MK, and Mueller D (2014).  Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of cocaine seeking.  Journal of Neuroscience 34: 6057-6064. 

Otis JM, Fitzgerald MK, and Mueller D (2014).  Inhibition of hippocampal β-adrenergic receptors impairs retrieval but not reconsolidation of cocaine-associated memory and prevents subsequent reinstatement. Neuropsychopharmacology 39: 303-310. 

Otis JM, Dashew KB, and Mueller D (2013).  Neurobiological dissociation of retrieval and reconsolidation of cocaine-associated memory.  Journal of Neuroscience 33:  1271-1281.

Otis JM and Mueller D (2011). Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement. Neuropsychopharmacology 36: 1912-1920.