Oates Research Lab

Professor and Director,
Division of Rheumatology & Immunology
Vice Chair for Research

The Oates Laboratory is focused on endothelial dysfunction and oxidative stress in systemic lupus erythematosus (SLE) and lupus nephritis (LN). Our work bridges basic science and translational research to develop novel therapeutic strategies aimed at improving vascular health in lupus patients.

One of our key areas of study is targeting eNOS uncoupling to determine if this approach can reduce kidney damage, enhance vascular function, and lower inflammation and oxidative stress markers in both murine LN models and cultured human glomerular endothelial cells.

We actively collaborate with experts in nephrology, including Oleg Palygin, Ph.D., and Justin van Beusecum, Ph.D., to explore how oxidative stress impacts endothelial function in conditions like hypertension, as well as Betty Tsao, Ph.D., studying the role of the lupus susceptibility variant NCF1-H90.

In partnership with Tammy Nowling, Ph.D., and Richard Drake, Ph.D., we are investigating N-glycan and glycosphingolipid biomarkers as potential mediators and indicators of lupus nephritis progression.

Additionally, we are exploring the impact of neighborhood-level environmental factors on lupus prevalence, healthcare utilization, and patient outcomes, with the goal of addressing disparities in lupus care and improving overall patient health.

Publications:

Google Scholar

PubMed Collection

Senior Author Publications:

Senior Author PubMed Collection (senior author publications are most often associated with mentored projects)