Jhou Laboratory Publications

The rostromedial tegmental (RMTg)“brake” on dopamine and behavior: A decade of progress but also much unfinished workT JhouNeuropharmacology, 108763

Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivityA Kruyer, J Parrilla-Carrero, C Powell, L Brandt, S Gutwinski, A Angelis, ...Molecular Psychiatry, 1-1

Prelimbic cortical projections to rostromedial tegmental nucleus play a suppressive role in cue-induced reinstatement of cocaine seekingAM Cruz, HF Spencer, TH Kim, TC Jhou, RJ SmithNeuropsychopharmacology 46 (8), 1399-1406

ALCOHOL DIFFERENTIALLY ALTERS NEURAL ACTIVITY IN THE PRELIMBIC PREFRONTAL CORTEX AND MEDIODORSAL THALAMUS SURROUNDING BOUTS OF ALCOHOL DRINKINGKP O'Hara, JA Rinker, TC Jhou, PJ MulhollandALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 45, 210A-210A

Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance BehaviorJ Parrilla-Carrero, M Eid, H Li, YS Chao, TC JhouJournal of Neuroscience 41 (21), 4620-4630

Entopeduncular nucleus projections to the lateral habenula contribute to cocaine avoidanceH Li, M Eid, D Pullmann, YS Chao, AA Thomas, TC JhouJournal of Neuroscience 41 (2), 298-306

Prepronociceptin-expressing neurons in the extended amygdala encode and promote rapid arousal responses to motivationally salient stimuliJ Rodriguez-Romaguera, RL Ung, H Nomura, JM Otis, ML Basiri, ...Cell reports 33 (6), 108362

Paranigral VTA Nociceptin Neurons Constrain Motivation for RewardK Parker, C Pedersen, A Gomez, S Spangler, M Walicki, S Feng, ...Biological Psychiatry 87 (9), S80-S81

Bidirectional valence encoding in the ventral pallidumPJ Vento, TC JhouNeuron 105 (5), 766-768

The ventrolateral periaqueductal grey updates fear via positive prediction errorRA Walker, KM Wright, TC Jhou, MA McDannaldEuropean Journal of Neuroscience 51 (3), 866-880

The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and MiceYN Zhao, YD Yan, CY Wang, WM Qu, TC Jhou, ZL Huang, SR YangNature and Science of Sleep 12, 1215

Three rostromedial tegmental afferents drive triply dissociable aspects of punishment learning and aversive valence encodingH Li, PJ Vento, J Parrilla-Carrero, D Pullmann, YS Chao, M Eid, TC JhouNeuron 104 (5), 987-999. e4

The Rostromedial Tegmental Nucleus Integrates Diverse Punishment Signals to Modulate Reward SeekingP Vento, M Eid, H Li, T Jhou NEUROPSYCHOPHARMACOLOGY 44 (SUPPL 1), 368-368

Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behaviorEJ Glover, EM Starr, Y Chao, TC Jhou, LJ ChandlerNeuropsychopharmacology 44 (11), 1896-1905

Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male ratsKM Wright, TC Jhou, D Pimpinelli, MA McDannaldElife 8, e50054

A paranigral VTA nociceptin circuit that constrains motivation for rewardKE Parker, CE Pedersen, AM Gomez, SM Spangler, MC Walicki, SY Feng, ...Cell 178 (3), 653-671. e19

Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and RewardJA Hardaway, LR Halladay, CM Mazzone, D Pati, DW Bloodgood, M Kim, ...Neuron 102 (5), 1037-1052. e7

THE ROLE OF RMTG-MEDIATED COCAINE AVERSION IN ADDICTION: A21M Eid, D Pullmann, H Li, T JhouJournal of Investigative Medicine 67 (5), 924-925

Bidirectional regulation of reward, punishment, and arousal by dopamine, the lateral habenula and the rostromedial tegmentum (RMTg)TC Jhou, PJ VentoCurrent Opinion in Behavioral Sciences 26, 90-96

Valence-encoding in the lateral habenula arises from the entopeduncular regionH Li, D Pullmann, TC JhoueLife 8, e41223

The rostromedial tegmental nucleus modulates the development of stress-induced helpless behaviorGI Elmer, H Palacorolla, CL Mayo, PL Brown, TC Jhou, D Brady, ...Behavioural brain research 359, 950-957

Generality and opponency of rostromedial tegmental (RMTg) roles in valence processingH Li, D Pullmann, JY Cho, M Eid, TC JhouElife 8, e41542282019Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and miceRJ Smith, PJ Vento, YS Chao, CH Good, TC JhouBrain Structure and Function 224 (1), 219-238

Multiple elements of addiction vulnerability are independently heritable in ratsM Eid, D Pullmann, H Li, A Thomas, TC JhoubioRxiv, 566018

The Role of the Rostromedial Tegmetal Nucleus in Cannabinoid RewardH Li, T Jhou, P Kalivas, S SpencerNEUROPSYCHOPHARMACOLOGY 43, S502-S503

INVOLVEMENTOF THE ROSTROMEDIAL TEGMENTAL NUCLEUS AND ITS INPUTS IN AVERSIVE ASPECTS OF ALCOHOL DEPENDENCEEJ Glover, EM Starr, TC Jhou, LJ ChandlerALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 42, 313A-313A

Cocaine self-administration and time-dependent decreases in prelimbic activityTS Dennis, TC Jhou, JF McGintybioRxiv, 25545532018The entopeduncular nucleus drives lateral habenula responses to negative but not positive or neutral affective stimuliH Li, D Pullmann, T JhouBioRxiv, 408963

Inhibition of the Rostromedial Tegmental Nucleus Reverses Withdrawal-Induced Negative AffectE Glover, EM Starr, N Burnham, Y Chao, T Jhou, LJ ChandlerNEUROPSYCHOPHARMACOLOGY 43, S325-S325

Learning from one’s mistakes: A dual role for the rostromedial tegmental nucleus in the encoding and expression of punished reward seekingPJ Vento, NW Burnham, CS Rowley, TC JhouBiological psychiatry 81 (12), 1041-1049

ADDICTION-LINKED DRUG AND ALCOHOL HISTORY RESULTS IN COMPULSIVE APPETITE VIA NON-HOMEOSTATIC PATHWAYSA Laque, A Matzeu, GE Wagner, G De Ness, T Kerr, TC Jhou, RC Ritter, ...ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 41, 36A-36A

Addiction-like synaptic impairments in diet-induced obesityRM Brown, YM Kupchik, S Spencer, C Garcia-Keller, DC Spanswick, ...Biological psychiatry 81 (9), 797-806

Inputs from the medial prefrontal cortex to the rostromedial tegmental nucleus are involved in signaling the aversive properties of alcoholEJ Glover, EM Starr, MJ McDougle, TC Jhou, LJ ChandlerAlcohol 100 (60), 223

The Lateral Habenula Circuitry: Reward Processing and Cognitive ControlPM Baker, T Jhou, B Li, M Matsumoto, SJY Mizumori, ...Journal of Neuroscience 36 (45), 11482-11488

Role for the rostromedial tegmental nucleus in signaling the aversive properties of alcoholEJ Glover, MJ McDougle, GS Siegel, TC Jhou, LJ ChandlerAlcoholism: Clinical and Experimental Research 40 (8), 1651-1661

Projections from the subparaventricular zone define four channels of output from the circadian timing systemN Vujovic, JJ Gooley, TC Jhou, CB SaperJournal of Comparative Neurology 523 (18), 2714-2737

Optogenetic Activation of the Sublaterodorsal (SLD) Nucleus Induces Rapid Muscle InhibitionCH Good, T Jhou, N BurnhamMEDICAL UNIV OF SOUTH CAROLINA CHARLESTON

Delineation of rostromedial tegmental nucleus (RMTG) in rats and mice via nociceptin/OFQ expression and anatomical connectivityR Smith, P Vento, T JhouJournal of Neurochemistry 134

Involvement Of The Rostromedial Tegmental Nucleus In Signaling The Aversive Properties Of Alcohol:135EJ Burnett, TC Jhou, LJ ChandlerAlcoholism: Clinical & Experimental Research 39, 283A

Efferent pathways of the mouse lateral habenulaLA Quina, L Tempest, L Ng, JA Harris, S Ferguson, TC Jhou, EE TurnerJournal of Comparative Neurology 523 (1), 32-60

P. 6. e. 001 History of cocaine self-administration leads to compulsive appetite via disruption of non-homeostatic control of food intake in ratsF Weiss, Y Hao, A Matzeu, G De Guglielmo, P Panday, T Kerr, ...European Neuropsychopharmacology 24, S697

Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the ratBS Bentzley, TC Jhou, G Aston-JonesProceedings of the National Academy of Sciences 111 (32), 11822-11827

The role of the rostromedial tegmental nucleus in ethanol withdrawalEJ Burnett, NW Burnham, JC Chandler, TC JhouALCOHOL 48 (2), 189-189

Rats Prone to Obesity Show'Addiction-like'Deficits in Behavior and Synaptic PlasticityRM Brown, YM Kupchik, S Spencer, C Garcia-Keller, D Schwartz, ...NEUROPSYCHOPHARMACOLOGY 38, S351-S352