Radhika Gudi, Ph.D.
Assistant Professor
Microbiology and Immunology
Education & Training
2007 Ph.D. University of Illinois at Chicago
2006-2011 Postdoctoral training Northwestern University
Contact Info
Lab: BS216
Tel: 843-792-9430
Office: 208E
Tel: 843-792-4339
Publications
Helke KL, Gudi R, Vasu C, Delaney JR. Combination of Autophagy Selective Therapeutics With Doxil: An Assessment of Pathological Toxicity. Front Toxicol. 2022 Jun 29;4:937150. doi: 10.3389/ftox.2022.937150. eCollection 2022.PMID: 35846434
Gudi R, Kamen D, Vasu C. Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels. .Clin Immunol. 2022 Sep; 242: 109107. PMID: 36049603
Gudi R, Karumuthil-Melethil S, Perez N, Li G, Vasu C (2022). Activation of T cell inhibitory pathways during β-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetes. Immunology. 2022 Apr 11. doi: 10.1111/imm.13476. Online ahead of print. PMID: 35404483
Gudi R, Roy S, Sun W, Vasu C (2022). Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus-prone mouse models. Immunology. 2022 Apr;165(4):497-507. doi: 10.1111/imm.13459. Epub 2022 Mar 1.PMID: 35138645
Gaudreau MC, Gudi R*, Li G, Johnson BM, Vasu C (2022). Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes. Autoimmunity. 2022 Mar;55(2):95-108. doi: 10.1080/08916934.2021.2012165. Epub 2021 Dec 9
Gudi R, Palanisamy V, and Vasu C* (2021). Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR. Sci Rep. 2021 Jun 16;11(1):12689. doi: 10.1038/s41598-021-91818-8.PMID: 34135376
Gudi R, Janakiraman H, Howe PH, Palanisamy V, Vasu C* (2021). Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer. Oncotarget. 2021 Apr 13;12(8):807-822. doi: 10.18632/oncotarget.27932. eCollection 2021 Apr 13.
Taylor HB, Gudi R, Brown R, Vasu C (2020). Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation. Nutrients. 2020 Jul 23;12(8):2193. doi: 10.3390/nu12082193.
Sun W, Gudi R, Johnson BM, Vasu C (2020). Abundance and nuclear-antigen reactivity of intestinal and fecal Immunoglobulin A in lupus-prone mice at younger ages correlate with the onset of eventual systemic autoimmunity. Nat Sci Rep. 2020 Aug 31;10(1):14258. doi: 10.1038/s41598-020-71272-8. PMID: 32868790.
Johnson MJ, Gaudreau MC, Gudi R, Brown R, Gilkeson G, Vasu C (2020). Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice. J Autoimmun. 2020 Mar;108: 102420. doi: 10.1016/j.jaut.2020.102420. PMID: 32019684.
Gudi R, Suber J, Brown R, Johnson BM, and Vasu C (2019). Pretreatment with yeast derived complex dietary-polysaccharide leads to suppressed gut inflammation, altered microbiota composition and increased immune regulatory short-chain fatty acid production in C57BL/6 mice. J Nutr. 2019 Dec 27. pii: nxz328. doi: 10.1093/jn/nxz328.
Gudi R, Karumuthil-Melethil S*, Perez N*, Li G, Vasu C (2019). Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance. Nature Sci. Rep. 2019 Aug 19;9(1):12065 PMID: 31427630.
Sofi MH, Johnson BM, Gudi R, Jolly A, Gaudreau MC, Vasu C (2019). Polysaccharide A-Dependent Opposing Effects of Mucosal and Systemic Exposures to Human Gut CommensalBacteroides Fragilis in Type 1 Diabetes. Diabetes. 2019 Jul 16. pii: db190211. doi: 10.2337/db19-0211. [Epub ahead of print]. PMID: 31311801
Gudi R, Perez N, Johnson BM, Sofi MH, Brown R, Quan S, Karumuthil-Melethil S, Vasu C (2019). Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes. Immunology. 2019 May;157(1):70-85. PMID: 30712258.
Kesarwani P, Chakraborty P, Gudi R, Chatterjee S, Scurti G, Toth K, Simms P, Husain M, Armeson K, Husain S, Garrett-Mayer E, Vasu C, Nishimura MI, Mehrotra S (2016). Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control. Oncotarget. 2016; 7(43):69371-69383. PubMed [journal] PMID: 27750220 PMCID: PMC5342484.
Johnson BM, Gaudreau MC, Al-Gadban MM, Gudi R, Vasu C (2015). Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice. Clin Exp Immunol. 2015 Aug;181(2):323-37. doi: 10.1111/cei.12609. PMID: 25703185.
Gudi R, Haycraft CJ, Bell PD, Li Z, Vasu C (2015). Centrobin-mediated regulation of CPAP level limits centriole length during elongation stage. J Biol Chem. 2015 Mar 13;290(11):6890-902. doi: 10.1074/jbc.M114.603423. Epub 2015 Jan 23. PMID: 25616662.
Sofi MH, Johnson BM, Gudi R, Wolf KJ, Lorenz RG, Vasu C (2015). Response to Comment on Sofi et al. pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence. Diabetes 2014;63:632-644. Diabetes. 2015 Aug;64(8):e20-1. doi: 10.2337/db15-0554. e-Letters: Comments and Responses.
Gaudreau MC, Johnson BM, Gudi R, Al-Gadban MM, Vasu C (2015). Gender bias in lupus: does immune response initiated in the gut mucosa have a role? Clin Exp Immunol. 2015 Jun;180(3):393-407. doi: 10.1111/cei.12587. Epub 2015 Apr 29. PMID: 25603723.
Gudi R, Zou C, Dhar J, Gao Q, Vasu C (2014). Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication. J Biol Chem. 2014 May 30;289(22):15166-78. doi: 10.1074/jbc.M113.531152. Epub 2014 Apr 3. PMID: 24700465.
Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C (2014). Fungal β-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response. J Immunol. 193(7):3308-21. PMID: 25143443.
Karumuthil-Melethil S, Sofi MH, Gudi R, Johnson BM, Perez N, and Vasu C (2014). TLR2 and Dectin 1-associated innate immune response modulates T cell response to pancreatic beta-cell antigen and prevents Type 1 diabetes. Diabetes. 2015 Apr;64(4):1341-57. doi: 10.2337/db14-1145. Epub 2014 Nov 5. PMID: 25377877.
Sofi MH, Gudi R, Karumuthil-Melethil S, Perez N, Johnson BM, Vasu C (2014). pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes;63(2):632-44. PMID: 24194504.
Gudi R, Zou C, Li J, Gao Q (2011). Centrobin-tubulin interaction is required for centriole elongation and stability. J Cell Biol. 2011 May 16;193(4):711-25. PubMed PMID: 21576394; PubMed Central PMCID: PMC3166857.
Gudi R, Barkinge J, Hawkins S, Prabhakar B, Kanteti P (2009). Siva-1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB. J Environ Pathol Toxicol Oncol. 2009;28(1):25-38. PubMed PMID: 19392652; PubMed Central PMCID: PMC4450717.
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV (2009). The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis. J Carcinog. 2009;8:2. PubMed PMID: 19240372; PubMed Central PMCID: PMC2678867.
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R (2009). Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. J Cell Sci. 2009 Aug 1;122(Pt 15):2651-61. PubMed PMID: 19584092.
Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV (2006). Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Oncogene. 2006 Jun 8;25(24):3458-62. PubMed PMID: 16491128.
