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About the Department of Biochemistry & Molecular Biology

Meet the chair, faculty, postdoctoral scholars, and staff who drive discovery and education in the Department of Biochemistry & Molecular Biology, strengthening research and training at MUSC. 

Philip H. Howe, Ph.D.

Chair, Department of Biochemistry & Molecular Biology

Philip H. Howe, Ph.D., joined the Medical University of South Carolina (MUSC) as the Hans & Helen Koebig Chair of Clinical Oncology in 2011, and now serves as chair of the Department of Biochemistry & Molecular Biology. Dr. Howe earned his Bachelor of Arts from Augusta University and his Doctor of Philosophy in Biochemistry from the Medical College of Georgia. After completing his postdoctoral training in Cell Biology at Vanderbilt University, he was a faculty member at Case Western University and the Cleveland Clinic before moving his lab to MUSC. Dr. Howe’s NIH and DOD funded research lab focuses on the role of transforming growth factor β1 (TGFβ1) in cellular models of differentiation and cancer.

Our Faculty

Our faculty bring deep expertise and a commitment to discovery that shapes breakthrough research and supports the growth of future scientists. Their drive to advance knowledge strengthens every part of our department.

 

Faculty Member Lab Website

Thibaut 'Tim' Barnoud, Ph.D.
Assistant Professor

Focus: The role of p53 variants in cancer risk and response to therapy; targeting heat shock proteins for the treatment of cancer.

 

Annamarie C. Dalton, Ph.D.
Assistant Professor

Focus: Molecular mechanisms of epithelial to mesenchymal transition effectors in cell-based and murine models of metastatic breast cancer and breast cancer recurrence in conjunction with Dr. Philip Howe.

 

Joseph Delaney, Ph.D.
Associate Professor

Focus: Biogenesis and pathology of copy-number alterations in cancer, particularly serous ovarian cancer.

View Delaney Lab

Raymond N. Dubois, M.D., Ph.D.
Professor

Focus: The molecular, genetic, and cellular basis for colorectal cancer.

 

Vamsi K. Gangaraju, Ph.D.
Associate Professor

Focus: Epigenetic regulation by Piwi-piRNA pathway; biogenesis and biological functions of piRNAs; environmental epigenetics; drosophila models of human diseases.

 
Saverio Gentile, Ph.D.
Associate Professor
 

Lu Han, Ph.D.
Assistant Professor

Focus: Epithelial-mesenchymal tissue interactions during pancreatic homeostasis and tumorigenesis.

View Han Lab

Jessica H. Hartman, Ph.D.
Assistant Professor

Focus: Individual differences in metabolism arising from genetic factors (e.g. xenobiotic metabolizing enzymes) and lifestyle factors (exercise and diet) that impact response to environmental exposures, especially mitochondrial function/dysfunction and ER stress.

View Hartman Lab

Aaron Hobbs, Ph.D.
Assistant Professor

 
Judit Jimenez Sainz, Ph.D.
Assistant Professor
View Jimenez Sainz Lab

David T. Long, Ph.D.
Professor

Focus: The mechanistic role of BRCA1 in DNA repair and cancer predisposition.

View Long Lab

Lalima K. Madan, Ph.D.
Assistant Professor

Focus: Protein-Phosphorylation based signaling

View Madan Lab

John P. O'Bryan, Ph.D.
Professor

Focus: Pathways regulating cell growth, development, differentiation and proliferation in response to growth factor receptor signaling.

View O'Bryan Lab

Besim Ogretmen, Ph.D.
Professor

Focus: Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance.

 

Michael C. Ostrowski, Ph.D.
Professor

Focus: Interactions between signaling pathways in cancer cell progression and normal cellular differentiation.

 

Jian Ouyang, Ph.D.
Assistant Professor

Focus: RNA-mediated genome maintenance and the transcriptional stress-induced genomic instability in normal and cancer cells, and targeting the underlying molecular mechanisms to develop novel cancer therapies.

 

Ozgur Sahin, Ph.D.
Professor

Focus: Mechanisms of cancer therapeutics, drug resistance and metastasis; drug discovery; systems biomedicine.

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Natalie Saini, Ph.D.
Assistant Professor

Focus: Determining the causes underlying genome instability in healthy humans, diseases with increased DNA damage and in cancers.

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Judit J. Sainz, Ph.D.
Assistant Professor
 

Russell Spencer-Smith, Ph.D.
Assistant Professor

Focus: Uncovering new vulnerabilities in the RAS-MAPK pathway through the study of rare disease-associated mutations.

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Daniel Sprague, M.D., Ph.D.
Assistant Professor

Focus: Neglected tropical diseases, cancer, and pain and depression. Utilizing techniques from various disciplines including synthetic and medicinal chemistry, pharmacology, and cell biology, we are interested in uncovering mechanisms of biased signaling in GPCRs and other receptors, studying epigenetic processes in both humans and parasites, and developing new ligands in un(der)drugged signaling pathways.

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Jennifer Stancill, Ph.D.
Assistant Professor

Focus: Determining the mechanisms by which pancreatic beta-cells protect themselves from reactive oxygen species and inflammation and how these mechanisms can be leveraged to prevent or treat diabetes.

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Timothy L. Stemmler, Ph.D.
Professor
 

Christina Voekel-Johnson, Ph.D.
Associate Professor

Focus: Cell death, sphingolipids, oxidative stress, gene delivery.

View Voelkel-Johnson Lab
Noel A. Warfel, Ph.D.
Associate Professor
 
Huimin Zhang, Ph.D.
Assistant Professor
 

Research Faculty

Aiping Bai, Ph.D.
Associate Professor

Bo Cen, Ph.D.
Assistant Professor

Breege V. Howley, Ph.D.
Assistant Professor

Sajish Mathew, Ph.D.
Assistant Professor

Patrick Nasarre, Ph.D.
Assistant Professor

Natalia V. Oleinik, Ph.D.
Assistant Professor

Sudarshana Sharma, Ph.D.
Associate Professor

Zdzislaw Szulc, Ph.D.
Associate Professor

Dingzhi Wang, Ph.D.
Professor

Jie Wei, MS
Associate Professor

Xingjun B. Wu, Ph.D.
Assistant Professor

Emeritus Faculty

Erika Büllesbach, Ph.D.
Associate Professor Emeritus
Focus: Hormones of insulin-like structure; chemical syntheses and structure-function relations.

Julie Chao, Ph.D.
Professor Emeritus
Focus: Serine proteinase structure-function relationship; purification, molecular cloning, expression, and function of proteinases and proteinase inhibitors; serpin regulation of gene expression

Daniel Fernandes, Ph.D.
Professor Emeritus
Focus: Molecular mechanisms of drug-induced gene amplification. Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II.

Paula Traktman Ph.D.
Hirschmann Endowed Professor Emeritus
Focus: Vaccinia virus genome replication and virion morphogenesis. The role(s) of the cellular VRK1 protein kinase and BANF1 protein in normal cell function and cancer.

Gregory W. Warr, Ph.D.
Professor Emeritus
Focus: Information Theory and its constraints on discrete systems in biology.

Our Administrators

Our administrative team supports department operations with care and precision. They help create a strong environment for research, education, and collaboration across the department.

 Name Contact Information
Megan E. White
Administrative Manager
843-792-4641
843-792-8304 (fax)
edge@musc.edu
Jennifer Rumble
Grants Administrator
843-792-3568
843-792-8304 (fax)
rumblej@musc.edu
Kate Mackiewicz
Administrative Coordinator to the Chair
843-792-9318
843-792-8304 (fax)
mackiewi@musc.edu
Erika Jenkins
Administrative Coordinator
843-792-8509
843-792-8304 (fax)
jenkinse@musc.edu
Shirley Toelle
Fiscal Technician II
843-792-5895
843-792-8304 (fax)
toellesj@musc.edu

Contact Our Department

MSC 509
173 Ashley Ave, Rm 501
Charleston, SC 29425

Phone: 843-792-9318

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