The Meissner lab studies the interface between the host immune system and chronic viral infections, with a specific interest in hepatitis B virus (HBV), the human immunodeficiency virus (HIV), and hepatitis C virus (HCV). The lab uses inducible pluripotent stem cells that have been differentiated into hepatocytes or macrophages to mechanistically explore how manipulation of the lambda interferon receptor (IFNLR1) influences the innate immune cellular response to viral infection and lambda interferon exposure. The overall goals of the research include improving our understanding mechanisms of disease pathogenesis, exploring mechanisms of acute and chronic inflammation mediated by interferons, and assessing whether manipulation of endogenous interferon signaling pathways can be employed to enhance inhibition of viral replication.
Publications
PubMed Collection
Senior Author Publications
Senior Author PubMed Collection (senior author publications are most often associated with mentored projects)
