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Guglietta Lab

Research Interests

In recent years, it emerged that the perturbation of the intestinal homeostasis does not only affect the local microenvironment but can have profound consequences on distant tissue sites. As such, the overall research interest of the lab is to understand how the interplay of intestinal immune responses and microbiome affect the development of diseases in the gastrointestinal tract as well as at distal sites.

Ongoing research in Guglietta lab encompasses four main areas:

  1. Interplay between complement anaphylatoxin C3a/C3aR axis, microbiota and immune responses in colon cancer development and inflammatory bowel diseases.
  2. The role of inflammation in the development and treatment of colorectal cancer.
  3. Identification of the immunological and microbial factors responsible for the disproportionate burden of colorectal cancer incidence and mortality in African Americans compared to Caucasian Americans.
  4. The role of the gut-brain axis in the development of neurodegenerative diseases.

Active Grants

(Active as August 2022)

COBRE Digestive and Liver Diseases- Pilot feasibility grant (11/01/2021- 10/31/2022)
"Role of the complement system in inflammatory bowel diseases"
Role: PI

NIH/NCI R01 (08/01/2022-07/31/2027)
Role of the complement C3a receptor on immune and non immune intestinal barrier functions and microbiota in colorectal cancer development"
Role: PI

Contact Information

Silvia Guglietta, Ph.D.
Assistant Professor

Room 206, Children's Research Institute
Office: 843-792-9702
Email: gugliett@musc.edu