Han Lab

The Han laboratory studies epithelial-mesenchymal tissue interactions during pancreatic homeostasis and tumorigenesis. Pancreatic cancer is one of the most lethal types of cancer, with only 11% of patients surviving five years after diagnosis. While pancreatic cancer is driven by mutations in the epithelial cells, it is characterized by a drastic increase of mesenchymal fibroblasts constituting the tumor microenvironment. These cancer associated fibroblasts (CAFs) play critical and complex roles that are still poorly understood. The Han laboratory aims to investigate the origin, diversity, and function of fibroblasts in pancreatic cancer. Given the remarkable similarities between cancer and development, we are particularly interested in the persistence of fetal developmental mechanisms regulating CAFs and their interactions with the tumor epithelium and other cells. We utilize genetically engineered mouse models, patient samples, organoids, and cell culture systems, analyzed with cutting edge cellular and molecular techniques such as multiplex immunofluorescence staining and transcriptomic sequencing. The missions of the Han laboratory are 1: to discover fundamental biological principles that can ultimately benefit cancer patients; and 2: to train and mentor the next generation of scientists.