Guglietta Lab

Research Interests

In recent years, it emerged that the perturbation of the intestinal homeostasis does not only affect the local microenvironment but can have profound consequences on distant tissue sites.
As such, the overall research interest of the lab is to understand how the interplay of intestinal immune responses and microbiome affect the development of diseases in the gastrointestinal tract as well as at distal sites.

Schematic of onging projects in the lab of Dr. Guglietta

Ongoing research in Guglietta lab encompasses four main areas:

  1. Interplay between complement anaphylatoxin C3a/C3aR axis, microbiota and immune responses in colon cancer development and inflammatory bowel diseases.
  2. The role of inflammation in the development and treatment of colorectal cancer.
  3. Identification of the immunological and microbial factors responsible for the disproportionate burden of colorectal cancer incidence and mortality in African Americans compared to Caucasian Americans.
  4. The role of the gut-brain axis in the development of neurodegenerative diseases.