Transplant Immunobiology Research

Surgery

Dr. Satish Nadig (center) and Dr. Carl Atkinson (far right) discuss their research with a postgraduate scholar

The research focus of the Lee Patterson Allen Transplant Immunobiology Laboratory is dedicated  to investigating novel innovations in transplant research. As a comprehensive research enterprise, we are interested in all aspects of transplantation spanning donor organ management to the induction of allograft tolerance. In addition, we are also investigating techniques that will lead to the next era of transplantation including bioengineering and artificial tissue development. 

Organ transplantation has become an accepted modality for the treatment of end-stage organ failure. The field of transplant medicine has made tremendous strides within the last thirty years, allowing for newer, more potent immunosuppressive medications rendering acute rejection episodes less frequent and less aggressive.

In spite of these accomplishments, chronic rejection remains a leading cause of graft loss in the long term. Various translational research efforts have identified pathways and potential therapeutics that may allay the effects of chronic rejection by conferring a tolerogenic phenotype in allograft recipients both in mouse and man. 

The Lee Patterson Allen Transplant Immunobiology Laboratory, led by Drs. Nadig and Atkinson, is dedicated to the study of innovative methods focused on tolerance induction in transplanted allografts.

Co-Directors

Satish Nadig, M.D., Ph.D.
Research on PubMed

Carl Atkinson Ph.D.
Research on PubMed

Research Scientists

David J. Taber, Pharm.D., BCPS: Dr. Taber's research focuses on optimizing transplant medication safety through Pharmacist-led mHealth based intervention. He is the PI of a $1,492,135 R18 study with the U.S. Department of Health & Human Services, Agency for Healthcare Research and Quality (AHRQ) 

John McGillicuddy, M.D.: Dr. McGillicuddy's research focuses on research to increase kidney transplant recipient graft survival. Dr.McGillicuddy is the PI of a $1.11 million National Institutes of Health grant to examine a novel use of mobile health technology to reduce kidney transplant recipient premature graft loss.

Research on PubMed

South Carolina Investigators in Transplantation: The South Carolina Investigators in Transplantation (SCIT) is comprised of a group of basic science and translational investigators whose laboratories have a specific focus in transplant immunology. 

MUSC Pediatric Transplant Program: The MUSC Health Transplant Center offers the most advanced pediatric transplant resources, facilities, and physicians skilled in the latest techniques, all focused on saving and improving the quality of young lives.