Image of liver cells

Clinical Component


The overarching goal of the MUSC DDRCC Clinical Component is to create a research support infrastructure of biostatisticians and research operations team members to promote efficiencies in the design, implementation, and analysis of research studies of therapies to improve clinical outcomes for patients with digestive diseases. MUSC has remarkable expertise in this area through the leadership of Paul J. Nietert, Ph.D., who has extensive collaborations in digestive disease research. He and the other members of the Clinical Component work with DDRCC members to receive statistical expertise and study operations in the planning of clinical as well as basic science research studies.

The DDRCC Clinical Component leverages the expertise of the MUSC Collaborative Unit (CU) in the Department of Public Health Science. This entire group has an extensive record of collaborative research in digestive and liver disease. Importantly, the CU has unparalleled statistical expertise for all phases of clinical and translational research. The team promotes an environment of collaboration, where they work closely with their partners on the design, planning, and conduct of research.

The Clinical Component team recommends early consultation for all research projects. Investigators are advised to submit a SCTR SPARC request (see procedure below) as soon as initial project goals take shape, designating Mat Gregoski as the point of contact. One of the team members will then contact the investigator to begin the collaboration.

To initate a collaboration with the Clinical Component Core:

1. Go to
2. Click on the green SCTR button on the left (middle of page)
3. Select: “Biostatistics, Design & Epidemiology
4. Enter any relevant study information, and make sure it is “submitted.”

For additional questions please contact:

Dr. Paul Nietert


Core Leader:

Paul J. Nietert, Ph.D.