Discoveries & Related Links

Discoveries

Repeated alcohol detoxifications can lead to an increase in seizure risk.
Use of benzodiazepines for multiple withdrawals is associated with increased drinking.
Outpatient alcohol withdrawal can be accomplished more safely with anticonvulsant medications.
Unique treatment challenges in treating individuals with AUD and comorbid conditions (anxiety, depression, PTSD).
Developed clinical laboratory procedures for evaluating medication effects on measures of craving and motivation to drink.
Developed animal models of alcohol dependence and relapse drinking that can be used as a platform to evaluate new and novel drug treatments.
Alcohol disrupts nerve cell functioning and neural network activity in prefrontal cortical areas of the brain.
Brains of individuals with alcohol use disorder react to alcohol cues differently from social drinkers and medications can “normalize” that reaction.
Transcranial magnetic stimulation (TMS) is a nonpharmacological intervention that holds promise as a novel therapeutic approach to reducing alcohol craving and facilitating enhanced cognitive (behavioral) control over drinking.
Sex-related differences in neuroadaptations to chronic alcohol may impact treatment strategies.
Pharmacogenetic analyses reveal significant modifying effects of genetics on treatment medication effects.

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