Palygin Research Lab

Professor and SmartState® Endowed Chair in Renal Disease Biomarkers
Division of Nephrology

Dr. Oleg Palygin is a Professor in the Division of Nephrology, Department of Medicine at the Medical University of South Carolina (MUSC). He earned his Ph.D. in Biophysics from the Bogomoletz Institute of Physiology in Kyiv, Ukraine, in 2004. Dr. Palygin completed postdoctoral training in renal physiology and neuroscience at the University of Iowa, University of Warwick (UK), and the Medical College of Wisconsin. He joined MUSC in 2021, continuing his innovative research on renal physiology and pathophysiology.

Dr. Palygin’s research focuses on the molecular and cellular mechanisms of kidney function, particularly the role of ion channels, transporters, and redox signaling in renal and cardiovascular health and disease. The Palygin lab investigates the intricate processes of electrolyte balance, albumin handling, and calcium signaling, exploring their implications in conditions such as diabetic kidney disease, polycystic kidney disease, lupus nephritis and salt-sensitive hypertension. A key area of interest in the Palygin lab is the investigation of oxidative and nitrosative stress in kidney damage.

Dr. Palygin’s lab is at the forefront of advanced imaging and physiological techniques, employing patch-clamp electrophysiology, multiphoton microscopy, biosensor amperometry, multiomics approach and intravital imaging to explore kidney function. Studies in Dr. Palygin’s lab have provided groundbreaking insights into the role of redox mechanisms in kidney pathophysiology and the interplay between glomerular and tubular cell signaling.

Publications

PubMed Collection

Bibliography