Jessica H. Hartman, Ph.D.

Assistant Professor
Department: Biochemistry and Molecular Biology
Programs: Cellular Injury, End Organ Disease

 

 

Research Interests:

Dr. Hartman received her Ph.D. in Biochemistry from University of Arkansas for Medical Sciences in Little Rock, AR. Following her postdoctoral training in Environmental Toxicology at the Nicholas School of the Environment at Duke University in Durham, NC, Dr. Hartman joined the MUSC faculty this year as a new member of the Biochemistry and Molecular Biology Department.

Dr. Hartman has a long-running interest in metabolism, and has made important contributions to the field of xenobiotic metabolism through her studies of the mammalian enzyme cytochrome P450 2E1 (CYP2E1). Her dissertation work focused on the endoplasmic reticulum-localized form of this enzyme (microsomal CYP2E1), enzymatic cooperativity in its metabolism of substrates, and its interaction with inhibitor ligands. More recently, she shifted her specific focus to mitochondrially-targeted CYP2E1 and its unique role in endogenous metabolism, cell signaling, and the deleterious production of reactive metabolites within mitochondria. Going forward, the Hartman lab will focus on how damage to mitochondrial macromolecules caused by these reactive metabolites contributes to the progression of diseases like alcoholic and non-alcoholic fatty liver.

The Hartman Laboratory is also interested in determining how lifestyle factors such as diet, alcohol/drug use, and exercise alter metabolism to impact toxicity from environmental exposures, with a special focus on mitochondrial toxicity and ER stress. She is currently funded by a K99/R00 grant from NIEHS to study how exercise reprograms metabolism to impact toxicity from exposures using the model organism Caenorhabditis elegans.

The Hartman Lab will use a combination of cell culture, C. elegans, and ex-vivo mammalian studies, to uncover mechanisms underlying inter-individual toxicity from exposures by better understanding how lifestyle factors change metabolism.

Publications:

PubMed Collection