The Gudi Lab


 Radhika Gudi photo

Radhika Gudi, Ph.D.

Assistant Professor
Microbiology and Immunology

Education & Training

2007 Ph.D. University of Illinois at Chicago
2006-2011 Postdoctoral training Northwestern University

Contact Info

Lab: BS216
Tel: 843-792-9430

Office: 208E
Tel: 843-792-4339


Research Interests

Identifying the canonical and non-canonical regulatory mechanisms that contribute towards centrosome structure and function, endocytic vesicular trafficking pathways and tumor suppression. Vesicular trafficking plays a critical homeostatic role in various cellular functions. Defects in this pathway can lead to malignancies and chronic inflammation.

My lab studies the fundamental, cellular regulatory mechanisms of vesicular transport in the context of cell surface receptor homeostasis, inflammation, centriole duplication and tumor prevention. We are also interested in developing novel therapeutic approaches that can target the vesicular transport pathway and prevent onset of cancer.


  1. Helke KL, Gudi R, Vasu C, Delaney JR. Combination of Autophagy Selective Therapeutics With Doxil: An Assessment of Pathological Toxicity. Front Toxicol. 2022 Jun 29;4:937150. doi: 10.3389/ftox.2022.937150. eCollection 2022.PMID: 35846434
  2. Gudi R, Kamen D, Vasu C. Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels. .Clin Immunol. 2022 Sep; 242: 109107. PMID: 36049603
  3. Gudi R, Karumuthil-Melethil S, Perez N, Li G, Vasu C (2022). Activation of T cell inhibitory pathways during β-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetes. Immunology. 2022 Apr 11. doi: 10.1111/imm.13476. Online ahead of print. PMID: 35404483
  4. Gudi R, Roy S, Sun W, Vasu C (2022). Preclinical stage abundance and nuclear antigen reactivity of faecal Immunoglobulin A vary among males and females of lupus-prone mouse models. Immunology. 2022 Apr;165(4):497-507. doi: 10.1111/imm.13459. Epub 2022 Mar 1.PMID: 35138645
  5. Gaudreau MC, Gudi R*, Li G, Johnson BM, Vasu C (2022). Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes. Autoimmunity. 2022 Mar;55(2):95-108. doi: 10.1080/08916934.2021.2012165. Epub 2021 Dec 9
  6. Gudi R, Palanisamy V, and Vasu C* (2021). Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR. Sci Rep. 2021 Jun 16;11(1):12689. doi: 10.1038/s41598-021-91818-8.PMID: 34135376
  7. Gudi R, Janakiraman H, Howe PH, Palanisamy V, Vasu C* (2021). Loss of CPAP causes sustained EGFR signaling and epithelial-mesenchymal transition in oral cancer. Oncotarget. 2021 Apr 13;12(8):807-822. doi: 10.18632/oncotarget.27932. eCollection 2021 Apr 13.
  8. Taylor HB, Gudi R, Brown R, Vasu C (2020). Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β-Glucan, Paramylon and the Impact on Gut Inflammation. Nutrients. 2020 Jul 23;12(8):2193. doi: 10.3390/nu12082193.
  9. Sun W, Gudi R, Johnson BM, Vasu C (2020). Abundance and nuclear-antigen reactivity of intestinal and fecal Immunoglobulin A in lupus-prone mice at younger ages correlate with the onset of eventual systemic autoimmunity. Nat Sci Rep. 2020 Aug 31;10(1):14258. doi: 10.1038/s41598-020-71272-8. PMID: 32868790.
  10. Johnson MJ, Gaudreau MC, Gudi R, Brown R, Gilkeson G, Vasu C (2020). Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice. J Autoimmun. 2020 Mar;108: 102420. doi: 10.1016/j.jaut.2020.102420. PMID: 32019684.
  11. Gudi R, Suber J, Brown R, Johnson BM, and Vasu C (2019). Pretreatment with yeast derived complex dietary-polysaccharide leads to suppressed gut inflammation, altered microbiota composition and increased immune regulatory short-chain fatty acid production in C57BL/6 mice. J Nutr. 2019 Dec 27. pii: nxz328. doi: 10.1093/jn/nxz328.
  12. Gudi R, Karumuthil-Melethil S*, Perez N*, Li G, Vasu C (2019). Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance. Nature Sci. Rep. 2019 Aug 19;9(1):12065 PMID: 31427630.
  13. Sofi MH, Johnson BM, Gudi R, Jolly A, Gaudreau MC, Vasu C (2019). Polysaccharide A-Dependent Opposing Effects of Mucosal and Systemic Exposures to Human Gut CommensalBacteroides Fragilis in Type 1 Diabetes. Diabetes. 2019 Jul 16. pii: db190211. doi: 10.2337/db19-0211. [Epub ahead of print]. PMID: 31311801
  14. Gudi R, Perez N, Johnson BM, Sofi MH, Brown R, Quan S, Karumuthil-Melethil S, Vasu C (2019). Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes. Immunology. 2019 May;157(1):70-85. PMID: 30712258.
  15. Kesarwani P, Chakraborty P, Gudi R, Chatterjee S, Scurti G, Toth K, Simms P, Husain M, Armeson K, Husain S, Garrett-Mayer E, Vasu C, Nishimura MI, Mehrotra S (2016). Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control. Oncotarget. 2016; 7(43):69371-69383. PubMed [journal] PMID: 27750220 PMCID: PMC5342484.
  16. Johnson BM, Gaudreau MC, Al-Gadban MM, Gudi R, Vasu C (2015). Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1 mice. Clin Exp Immunol. 2015 Aug;181(2):323-37. doi: 10.1111/cei.12609. PMID: 25703185.
  17. Gudi R, Haycraft CJ, Bell PD, Li Z, Vasu C (2015). Centrobin-mediated regulation of CPAP level limits centriole length during elongation stage. J Biol Chem. 2015 Mar 13;290(11):6890-902. doi: 10.1074/jbc.M114.603423. Epub 2015 Jan 23. PMID: 25616662.
  18. Sofi MH, Johnson BM, Gudi R, Wolf KJ, Lorenz RG, Vasu C (2015). Response to Comment on Sofi et al. pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence. Diabetes 2014;63:632-644. Diabetes. 2015 Aug;64(8):e20-1. doi: 10.2337/db15-0554. e-Letters: Comments and Responses.
  19. Gaudreau MC, Johnson BM, Gudi R, Al-Gadban MM, Vasu C (2015). Gender bias in lupus: does immune response initiated in the gut mucosa have a role? Clin Exp Immunol. 2015 Jun;180(3):393-407. doi: 10.1111/cei.12587. Epub 2015 Apr 29. PMID: 25603723.
  20. Gudi R, Zou C, Dhar J, Gao Q, Vasu C (2014). Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication. J Biol Chem. 2014 May 30;289(22):15166-78. doi: 10.1074/jbc.M113.531152. Epub 2014 Apr 3. PMID: 24700465.
  21. Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N, Vasu C (2014). Fungal β-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response. J Immunol. 193(7):3308-21. PMID: 25143443.
  22. Karumuthil-Melethil S, Sofi MH, Gudi R, Johnson BM, Perez N, and Vasu C (2014). TLR2 and Dectin 1-associated innate immune response modulates T cell response to pancreatic beta-cell antigen and prevents Type 1 diabetes. Diabetes. 2015 Apr;64(4):1341-57. doi: 10.2337/db14-1145. Epub 2014 Nov 5. PMID: 25377877.
  23. Sofi MH, Gudi R, Karumuthil-Melethil S, Perez N, Johnson BM, Vasu C (2014). pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes;63(2):632-44. PMID: 24194504.
  24. Gudi R, Zou C, Li J, Gao Q (2011). Centrobin-tubulin interaction is required for centriole elongation and stability. J Cell Biol. 2011 May 16;193(4):711-25. PubMed PMID: 21576394; PubMed Central PMCID: PMC3166857.
  25. Gudi R, Barkinge J, Hawkins S, Prabhakar B, Kanteti P (2009). Siva-1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB. J Environ Pathol Toxicol Oncol. 2009;28(1):25-38. PubMed PMID: 19392652; PubMed Central PMCID: PMC4450717.
  26. Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV (2009). The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis. J Carcinog. 2009;8:2. PubMed PMID: 19240372; PubMed Central PMCID: PMC2678867.
  27. Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R (2009). Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis. J Cell Sci. 2009 Aug 1;122(Pt 15):2651-61. PubMed PMID: 19584092.
  28. Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV (2006). Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Oncogene. 2006 Jun 8;25(24):3458-62. PubMed PMID: 16491128.