Pandey Lab

Janardan P. Pandey, Ph.D.
Professor
Microbiology & Immunology

Education
1972 Ph.D., University of Wisconsin, Madison

Contact Info
pandeyj@musc.edu
Tel: 843-792-4360
BSB 753A-B

Research Interests
The primary focus of my laboratory is directed towards understanding the mechanisms underlying the involvement of immunoglobulin Fc (GM) and Fc gamma receptor genes in immunity to various malignant and infectious diseases. These studies are supported in part by grants and contracts from the National Institutes of Health and the Cystic Fibrosis Foundation.

Recent Publications | Additional Publications
Gaudinski MR, Coates EE, Houser KV, Chen GL, Yamshchikov G, Saunders JG, Holman LA, Gordon I, Plummer S, Hendel CS, Conan-Cibotti M, Lorenzo MG, Sitar S, Carlton K, Laurencot C, Bailer RT, Narpala S, McDermott AB, Namboodiri AM, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE. Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults. VRC 606 Study Team. PLoS Med. 2018 Jan 24;15(1): e1002493. doi: 10.1371/journal.pmed.1002493. eCollection 2018 Jan. PMID:29364886

Pandey JP. HIV-1 Control and Immunoglobulin Genes.  J Infect Dis. 2018 Mar 13;217(7):1170. doi: 10.1093/infdis/jiy021. No abstract available. PMID:29346629

Pandey JP, Namboodiri AM, Wolf B, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S. Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.  Immunobiology. 2018 Feb;223(2):178-182. doi: 10.1016/j.imbio.2017.10.028. Epub 2017 Oct 18. PMID:29074302

Di Bona D, Accardi G, Aiello A, Bilancia M, Candore G, Colomba C, Caruso C, Duro G, Gambino CM, Macchia L, Pandey JP. Association between γ marker, human leucocyte antigens and killer immunoglobulin-like receptors and the natural course of human cytomegalovirus infection: a pilot study performed in a Sicilian population.  Immunology. 2018 Apr;153(4):523-531. doi: 10.1111/imm.12855. Epub 2017 Dec 11. PMID:29067686

Pandey JP, Namboodiri AM, Nietert PJ, Yoshimura R, Hori H. Immunoglobulin genotypes and cognitive functions in schizophrenia.  Immunogenetics. 2018 Jan;70(1):67-72. doi: 10.1007/s00251-017-1030-6. Epub 2017 Sep 22. PMID:28936707

Pandey JP. Rituximab therapy and the highly polymorphic Fc region of IgG: comment on the article by Cartin-Ceba et al.  Arthritis Rheumatol. 2017 Nov;69(11):2247. doi: 10.1002/art.40221. No abstract available. PMID:28743175

Pandey JP, Namboodiri AM, Mohan S, Nietert PJ, Peterson L. Genetic markers of immunoglobulin G and immunity to cytomegalovirus in patients with breast cancer. Cell Immunol. 2017 Feb;312:67-70. doi: 10.1016/j.cellimm.2016.11.003. Epub 2016 Nov 2. PMID:27825564

Okusaga O, Fuchs D, Reeves G, Giegling I, Hartmann AM, Konte B, Friedl M, Groer M, Cook TB, Stearns-Yoder KA, Pandey JP, Kelly DL, Hoisington AJ, Lowry CA, Eaton WW, Brenner LA, Rujescu D, Postolache TT. Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies. Psychosom Med. 2016 Oct;78(8):931-939.
PMID:27359171

Pandey JP, Namboodiri AM, Elston RC. Immunoglobulin G genotypes and the risk of schizophrenia.  Hum Genet. 2016 Oct;135(10):1175-9. doi: 10.1007/s00439-016-1706-2. Epub 2016 Jul 8. PMID:27393575

Pandey JP. Significance of FcγRIIIa-V158F Polymorphism-Letter.  Clin Cancer Res. 2016 May 1;22(9):2311. doi: 10.1158/1078-0432.CCR-16-0428. No abstract available. PMID:27141008

Research Support
NIH/NIAID/Leidoos 04/01/2016-08/30/2021
(Consultant to the NIAID Vaccine Research Center)
GM Allotypes and the pharmacokinetics of broadly neutralizing HIV1 human monoclonal antibodies
Role: PI of the subcontract

Cystic Fibrosis Foundation 07/01/2018-06/30/2021 Pandey (PI)
PANDEY18PO
IGHG and IGKC Genes and Lung Disease Severity in Cystic Fibrosis
Role: PI

NIH
U54 MD010706 7/8/16-03/31/2021 (Hughes-Halbert)
MUSC Transdisciplinary Collaborative Center in Precision Medicine and Minority Men’s Health
My sub project investigates the role of GM and KM allotypes in the efficacy of PROSTVAC vaccine.
Role: Collaborator

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