Cowan Laboratory Publications

Published, In Press or Accepted Original Research Papers

  • Taniguchi, M., Carreira, M.B., Cooper, Y.A., Bobadilla, A.-C., Heinsbroek, J.A., Koike, N., Larson. E.B., Balmuth, E.A., Hughes, B.W., Penrod, R.D., Kumar, J., Smith, L.N., Guzman, D., Takahashi, J.S., Kim, T.-K., Kalivas, P.W., Self, D.W., Lin, Y., Cowan, C.W. HDAC5 and its target gene, NPAS4, regulate cocaine conditioned behaviors in the nucleus accumbens. Neuron, 2017, 96(1): 130 to 144. PMID: 28957664 (2017).
  • Penrod, R.D., Carreira, M.B., Taniguchi, M., Kumar, J., Maddox, S.A., Cowan, C.W. Novel role and regulation of HDAC4 in cocaine-related behaviors. Addiction Biology, dol:10.1111/adb.12522 (2017).
  • Harrington, A.J., Raissi, A., Kumar, J., Rajkovich, K., Raduazzo, J., Guo, Y., Loerwald, K., Huber, K.A., Cowan, C.W. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. eLife, 10.7554/eLife.20059 (2016).
  • Robichaux, M.A., Chenaux, G., Ho, H.-Y.H., Soskis, M.J., Greenberg, M.E., Henkemeyer, M., Cowan, C.W. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure. Dev. Neurobiology, 76(4): 405 to 420 (2016).
  • Smith, L.N., Jedynak, J.P., Fontenot, M.R., Hale, C.F., Dietz, K.C., Taniguchi, M., Thomas, F.S., Zirlin, B.C., Birnbaum, S.G., Huber, K.M., Thomas, M.J., Cowan, C.W. Fragile X Mental Retardation Protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron, 82(3): 645 to 58 (2014). Video highlight for this article: Neuron online (2014)
  • Robichaux, M.A., Chenaux, G., Ho, H.-Y.H., Soskis, M.J., Soskis, C., Kwan, K.Y., Sestan, N., Greenberg, M.E., Henkemeyer, M., Cowan, C.W. EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon guidance. Proc. Natl. Acad. Sci., USA, 111(6): 2188 to 93 (2014).
  • Zang, T., Maksimova, M., Cowan, C.W., Bassel-Duby, R., Olson, E.N., Huber, K.M. Postsynaptic FMRP bi-directionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol. Cell. Neurosci., 56: 39 to 49 (2013).
  • Srivastava, N., Robichaux, M.A., Chenaux, G., Henkemeyer, M., Cowan, C.W. EphB receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol. Cell. Neurosci., 52: 106 to 16 (2013).
  • Tsai, N.-P., Wilkerson, J.R., Guo, W., Maksimova, M., DeMartino, G.N., Cowan, C.W., Huber, K.M. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell, 151(7): 1581 to 94 (2012).
  • Soskis, M.J., Ho, H.-Y. H., Bloodgood, B., Robichaux, M.R., Malik, A., Ataman, B., Rubin, A.A., Zhang, C., Shokat, K., Sharma, N., Cowan, C.W., Greenberg, M.E. A chemical genetic approach reveals a requirement for EphB Receptor tyrosine kinase activity in axon guidance but not synaptogenesis. Nature Neurosci., 15(12): 1645 to 54 (2012).
  • Wang, Y., He, H., Srivastava, N., Vikarunnessa, S., Chen, Y.-B., Jiang, J., Cowan, C.W., Zhang, X. Plexins are GTPase Activating Proteins for Rap and are activated by induced dimerization. Science Signal., 5(207):ra6 (2012).
  • Taniguchi, M., Carreira, M.B., Smith, L.N., Zirlin, B.C., Neve, R.L., Cowan, C.W. Histone Deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron, 73(1): 108 to 20 (2012).

    Preview for this article: West AE. Regulated Shuttling of the Histone Deacetylase HDAC5 to the Nucleus May Put a Brake on Cocaine Addiction. Neuron, 73(1), 1 to 2 (2012); Editors’ Choice for this article: Histone Deacetylates: Cocaine controls nuclear import. Sci. Signal., 5(207), ec18 (2012); Research Highlight for this article: Yates, D. “Addiction: Curtailing reward”, Nature Reviews Neurosci., 13: 151 (2012).
  • Hale, C.F., Dietz, K.C., Varela, J.A., Wood, C.B., Zirlin, B.C., Leverich, L.S., Greene, R.W., Cowan, C.W. Essential role for Vav GEFs in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. J. Neurosci., 31(35): 12426 to 12436 (2011).
  • Pfeiffer, B.E., Zang, T., Wilkerson, J., Taniguchi, M., Maksimova, M.A., Smith, L.N., *Cowan, C.W., *Huber, K.M. Fragile X Mental Retardation Protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron, 66: 191 to 197 (2010). (*corresponding authors)
  • Meyer, D.A., Richer, E., Benkovic, S.A., Hayashi, K., Kansy, J.W., Hale, C., Moy, L., Kim, Y., O’Callaghan, J.P., Tsai, L.-H., Greengard, P., Nairn, A.C., Cowan, C.W., Miller, D.B., Antich, P., Bibb, J.A. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc. Natl. Acad. Sci., USA, 105: 18561 to 6 (2008).
  • Pulliparacharuvil, S.G., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G., Kumar, A., Dewey, C.M., Davis, M., Nairn, A., Greengard, P., Nestler, E.J., Cowan, C.W. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron, 59: 621 to 33 (2008). 

    News and Views” on this article: Chandler LJ and Kalivas PW. Neuroscience: Brain’s defence against cocaine. Nature, 455: 743 to 4 (2008); “Research Highlights” on this article: Neuroscience, Coke Heads. Nature, 455: 5 (2008); “Research Findings” on this article: “Brain adaptation may dampen effects of cocaine”. NIDA Notes, (2010).
  • Hunter, S.G., Zhuang, G., Brantley-Sieders, D., Swat, W., Cowan, C.W., Chen, J. Essential role of Vav family GEFs in EphA receptor-mediated angiogenesis. Mol. Cell Biol., 26: 4830 to 42 (2006).
  • *Flavell, S.W., *Cowan, C.W., Kim, T.K., Greer, P.L., Lin, Y., Paradis, S., Griffith, E.C., Hu, L.S., Chen, C., Greenberg, M.E. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science, 311: 1008 to 12 (2006). (*authors contributed equally)

    Perspectives” on this article: Beg AA and Scheiffele P. Neuroscience: SUMO wrestles the synapse. Science, 311: 962 to 63 (2006); “Leading Edge” on this article: Neurobiology Select: Putting the brakes on synapse number. Cell, 125: 207 (2006).
  • Cowan, C.W., Shao, Y.R., Sahin, M., Shamah, S.M., Lin, M.Z., Greer, P.L., Gao, S., Griffith, E.C., Brugge, J.S., Greenberg, M.E. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron, 46: 205 to 17 (2005).

    Preview for this article: Murai KK and Pasquale EB. New exchanges in Eph-dependent growth cone dynamics. Neuron, 46: 161-3 (2005).
  • Sahin, M., Greer, P.L., Lin, M.Z., O'Connell, S., Wright, T.M., Shamah, S.M., Eberhart, J., Cowan, C.W., Hu, L., Goldberg, J.L., Krull, C.E., Corfas, G., Greenberg, M.E. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron, 46: 191 to 204 (2005).
  • Sturla, L.-M., Cowan, C.W., Guenther, L., Castellino, R.C., Kim, J.Y.H., Pomeroy, S.L. A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Res, 65: 5683 to 9 (2005).
  • Datta, S.R., Ranger, A.M., Lin, M.Z., Sturgill, J.F., Ma, Y.C., Cowan, C.W., Dikkes, P., Korsmeyer, S.J., Greenberg, M.E. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell, 3: 631 to 43 (2002).
  • Kornhauser, J.M., Cowan, C.W., Shaywitz, A.J., Dolmetsch, R.E., Griffith, E.C., Hu, L.S., Haddad, C., Xia, Z., Greenberg, M.E. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron, 34: 221 to 33 (2002).

    Minireview for this article: Deisseroth, K. and Tsien, R.W. Dynamic multiphosphorylation passwords for activity-dependent gene expression. Neuron, 34:179 to 182 (2002).
  • He, W., Melia, T.J., Cowan, C.W., Wensel, T.G. Dependence of RGS9-1 membrane attachment on its C-terminal tail. J. Biol. Chem., 276: 48961 to 6 (2001).
  • Hu, G., Jang, G.-F., Cowan, C.W., Wensel, T.G., Palczewski, K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J. Biol. Chem., 276: 22287 to 95 (2001).
  • Slep, K.C., Kerchner, M.A., He, W., Cowan, C.W., Wensel, T.G., Sigler, P.B. Structural determinants for regulation of phosphodiesterase by a G-protein at 2.0 angstroms. Nature, 409: 1071-7 (2001).
  • He, F., Seryshev, A.B., Cowan, C.W., Wensel, T.G. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase. J. Biol. Chem., 275: 20572 to 7 (2000).
  • Rahman, Z., Gold, S.J., Potenza, M.N., Cowan, C.W., Ni, Y.G., He, W., Wensel, T.G., Nestler, E.J. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. J. Neurosci., 19: 2016-2026 (1999).
  • Cowan, C.W., Farris, R.N., Sokal, I., Palczewski, K., Wensel, T.G. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc. Natl. Acad. Sci., USA, 95: 5351 to 5356 (1998).
  • *He, W., *Cowan, C.W., Wensel, T.G. RGS9, a GTPase accelerator for vision. Neuron, 20: 95 to 102 (1998). (*authors contributed equally)

    Minireview for this article: Arshavsky VY and Pugh EN. Lifetime regulation of the G protein-effector complex: emerging importance of RGS proteins. Neuron, 20:11 to 14 (1998).
  • Melia, T.J., Cowan, C.W., Angleson, J.K., Wensel, T.G. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys. J., 73: 3182 to 3191 (1997).
  • Adams, D.B., Cowan, C.W., Marshall, M.E., Stark, J. Competitive and territorial fighting: two types of offense in the rat. Physiol. Behav., 55: 247-54 (1994).
  • Adams, D.B., Boudreau, W., Cowan, C.W., Kokonowski, C., Oberteuffer, K., Yohay, K.Offense produced by chemical stimulation of the anterior hypothalamus of the rat. Physiol. Behav., 53: 1127 to 1132 (1993).

Invited Book Chapters, Review Articles, Perspectives & Misc. Material

  • Smith, L.N., Penrod, R.D., Taniguchi, M. and Cowan, C.W. Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice. J. Vis. Exp., 108 (2016). Invited Chapter.
  • Penrod, R.D., Wells, A.M., Carlezon, Jr., W.A., Cowan, C.W. Use of Adeno-Associated and Herpes Simplex Viral Vectors for In Vivo Neuronal Expression in Mice. Curr. Protoc. Neurosci., 73: 37.1 to 31 (2015). Invited Chapter.
  • Cowan, C.W. Viewpoint: Misdirected neurons may underlie autism symptoms. Simons Foundation website (2014). Invited Perspective.
  • Robichaux, M.A. and Cowan, C.W. Signaling Mechanisms of Axon Guidance and Early Synaptogenesis. Curr. Top. Behav. Neurosci. 16:19 to 48 (2014). Invited Book Chapter.
  • Smith, L.N. and Cowan, C.W. News and Views: Striking a Balance in Fragile X. Nat. Medicine, 19(11): 1370 to 1 (2013). Invited Preview.
  • Rothenfluh, A. and Cowan, C.W. The role of actin regulating proteins in drug-induced structural and behavioral plasticity: actin or reactin’. Curr. Opin. Neurobiol. 23(4): 507 to 12 (2013). Invited Perspective.
  • Shen, K. and Cowan, C.W. Guidance Molecules in Synapse Formation and Plasticity. Neuronal Guidance: The Biology of Brain Wiring, Tessier-Lavigne, M. and Kolodkin, A.L. eds. Cold Spring Harbor Press, 311 to 328 (2010). Invited Book Chapter.
  • Cowan, C.W., Hale, C.F., Taniguchi, M. Regulation of synaptic connectivity with chronic cocaine. Images in Neuroscience: Tamminga, C.A. ed. Am. J. Psychiatry, 165(11): 1393 (2008). Invited Perspective.
  • Griffith, E.C., Cowan, C.W., Greenberg, M.E. REST acts through multiple deacetylase complexes. Neuron, 31: 339 to 40 (2001). Invited Preview.
  • Cowan, C.W., He, W., Wensel, T.G. RGS proteins: lessons from the RGS9 subfamily and phototransduction. Prog. Nucleic Acid Res. Mol. Biol., 65: 341 to 59 (2000). Invited Review.
  • Cowan, C.W., Wensel, T.G., Arshavsky, V.Y. Enzymology of GTPase acceleration in phototransduction. Methods Enzymol., 315: 524 to 38 (2000). Invited Chapter.