Joseph Laboratory Publications

Donohew L, DiBartolo M, Zhu X, Benca C, Lorch E, Noar SM, Kelly TH, Joseph JE. Communicating with Sensation Seekers: An fMRI Study of Neural Responses to Antidrug Public Service Announcements. Health Commun. 2018 Aug;33(8):1004-1012. doi: 10.1080/10410236.2017.1331185. Epub 2017 Jun 16. PubMed PMID: 28622027; PubMed Central PMCID: PMC6190582.

Moran-Santa Maria MM, Vanderweyen DC, Camp CC, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study. Nicotine Tob Res. 2018 Jun 7;20(7):810-818. doi: 10.1093/ntr/ntx206. PubMed PMID: 29059410; PubMed Central PMCID: PMC5991199.

Taheri S, Xun Z, See RE, Joseph JE, Reichel CM. Cocaine and methamphetamine induce opposing changes in BOLD signal response in rats. Brain Res. 2016 Jul 1;1642:497-504. doi: 10.1016/j.brainres.2016.04.040. Epub 2016 Apr 18. PubMed PMID: 27103569; PubMed Central PMCID: PMC4899179.

Zhu X, Bhatt RS, Joseph JE. Pruning or tuning? Maturational profiles of face specialization during typical development. Brain Behav. 2016 Jun;6(6):e00464. doi: 10.1002/brb3.464. eCollection 2016 Jun. PubMed PMID: 27313976; PubMed Central PMCID: PMC4907975.

Lal C, DiBartolo MM, Kumbhare S, Strange C, Joseph JE. Impact of obstructive sleep apnea syndrome on cognition in early postmenopausal women. Sleep Breath. 2016 May;20(2):621-6. doi: 10.1007/s11325-015-1261-4. Epub 2015 Sep 18. PubMed PMID: 26385776.

Joseph JE, Zhu X, Lynam D, Kelly TH. Modulation of meso-limbic reward processing by motivational tendencies in young adolescents and adults. Neuroimage. 2016 Apr 1;129:40-54. doi: 10.1016/j.neuroimage.2015.12.005. Epub 2015 Dec 12. PubMed PMID: 26690806; PubMed Central PMCID: PMC4803600.

Hanlon CA, Owens MM, Joseph JE, Zhu X, George MS, Brady KT, Hartwell KJ. Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers. Addict Biol. 2016 Jan;21(1):185-95. doi: 10.1111/adb.12171. Epub 2014 Aug 13. PubMed PMID: 25125263; PubMed Central PMCID: PMC4326619.

Pushkarskaya H, Smithson M, Joseph JE, Corbly C, Levy I. Neural Correlates of Decision-Making Under Ambiguity and Conflict. Front Behav Neurosci. 2015;9:325. doi: 10.3389/fnbeh.2015.00325. eCollection 2015. PubMed PMID: 26640434; PubMed Central PMCID: PMC4661279.

Zhu X, Kelly TH, Curry TE Jr, Lal C, Joseph JE. Altered functional brain asymmetry for mental rotation: effect of estradiol changes across the menstrual cycle. Neuroreport. 2015 Sep 30;26(14):814-9. doi: 10.1097/WNR.0000000000000429. PubMed PMID: 26222958; PubMed Central PMCID: PMC4549195.

Joseph JE, DiBartolo MD, Bhatt RS. Developmental changes in analytic and holistic processes in face perception. Front Psychol. 2015;6:1165. doi: 10.3389/fpsyg.2015.01165. eCollection 2015. PubMed PMID: 26300838; PubMed Central PMCID: PMC4528094.

Joseph JE, Zhu X, Gundran A, Davies F, Clark JD, Ruble L, Glaser P, Bhatt RS. Typical and atypical neurodevelopment for face specialization: an FMRI study. J Autism Dev Disord. 2015 Jun;45(6):1725-41. doi: 10.1007/s10803-014-2330-4. PubMed PMID: 25479816; PubMed Central PMCID: PMC4442764.

Gerlach C, Zhu X, Joseph JE. Structural similarity exerts opposing effects on perceptual differentiation and categorization: an FMRI study. J Cogn Neurosci. 2015 May;27(5):974-87. doi: 10.1162/jocn_a_00748. Epub 2014 Nov 12. PubMed PMID: 25390196.

Lal C, White DR, Joseph JE, van Bakergem K, LaRosa A. Sleep-disordered breathing in Down syndrome. Chest. 2015 Feb;147(2):570-579. doi: 10.1378/chest.14-0266. Review. PubMed PMID: 25644910.

Joseph JE, Zhu X, Corbly CR, DeSantis S, Lee DC, Baik G, Kiser S, Jiang Y, Lynam DR, Kelly TH. Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior. Neuroimage. 2015 Jan 1;104:373-85. doi: 10.1016/j.neuroimage.2014.09.037. Epub 2014 Sep 23. PubMed PMID: 25261001; PubMed Central PMCID: PMC4257498.

Prisciandaro JJ, Joseph JE, Myrick H, McRae-Clark AL, Henderson S, Pfeifer J, Brady KT. The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues. Addiction. 2014 Dec;109(12):2062-70. doi: 10.1111/add.12666. Epub 2014 Jul 21. PubMed PMID: 24938849; PubMed Central PMCID: PMC4229403.

Zieber N, Kangas A, Hock A, Hayden A, Collins R, Bada H, Joseph JE, Bhatt RS. Perceptual specialization and configural face processing in infancy. J Exp Child Psychol. 2013 Nov;116(3):625-39. doi: 10.1016/j.jecp.2013.07.007. Epub 2013 Aug 28. PubMed PMID: 23994509; PubMed Central PMCID: PMC3796849.

Chester DS, Powell CA, Smith RH, Joseph JE, Kedia G, Combs DJ, DeWall CN. Justice for the average Joe: the role of envy and the mentalizing network in the deservingness of others' misfortunes. Soc Neurosci. 2013;8(6):640-9. doi: 10.1080/17470919.2013.846278. Epub 2013 Oct 18. PubMed PMID: 24138447.

Sequeira KM, Tabesh A, Sainju RK, DeSantis SM, Naselaris T, Joseph JE, Ahlman MA, Spicer KM, Glazier SS, Edwards JC, Bonilha L. Perfusion network shift during seizures in medial temporal lobe epilepsy. PLoS One. 2013;8(1):e53204. doi: 10.1371/journal.pone.0053204. Epub 2013 Jan 14. PubMed PMID: 23341932; PubMed Central PMCID: PMC3544909.

Collins HR, Zhu X, Bhatt RS, Clark JD, Joseph JE. Process and domain specificity in regions engaged for face processing: an fMRI study of perceptual differentiation. J Cogn Neurosci. 2012 Dec;24(12):2428-44. doi: 10.1162/jocn_a_00273. Epub 2012 Jul 31. PubMed PMID: 22849402; PubMed Central PMCID: PMC4527533.

Joseph JE, Swearingen JE, Clark JD, Benca CE, Collins HR, Corbly CR, Gathers AD, Bhatt RS. The changing landscape of functional brain networks for face processing in typical development. Neuroimage. 2012 Nov 15;63(3):1223-36. doi: 10.1016/j.neuroimage.2012.08.021. Epub 2012 Aug 11. PubMed PMID: 22906788; PubMed Central PMCID: PMC3637657.

Collins HR, Corbly CR, Liu X, Kelly TH, Lynam D, Joseph JE. Too little, too late or too much, too early? Differential hemodynamics of response inhibition in high and low sensation seekers. Brain Res. 2012 Oct 24;1481:1-12. doi: 10.1016/j.brainres.2012.08.004. Epub 2012 Aug 8. PubMed PMID: 22902769; PubMed Central PMCID: PMC3637656.

Bonilha L, Nesland T, Martz GU, Joseph JE, Spampinato MV, Edwards JC, Tabesh A. Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures. J Neurol Neurosurg Psychiatry. 2012 Sep;83(9):903-9. doi: 10.1136/jnnp-2012-302476. Epub 2012 Jul 4. PubMed PMID: 22764263; PubMed Central PMCID: PMC3415309.

Hayden A, Batt RS, Kangas A, Zieber N, Joseph JE. Race-Based Perceptual Asymmetry in Face Processing Is Evident Early in Life. Infancy. 2012 Sep;17(5):578-590. doi: 10.1111/j.1532-7078.2011.00098.x. Epub 2011 Oct 20. PubMed PMID: 32693547; PubMed Central PMCID: PMC7668310.

Lawson AL, Liu X, Joseph J, Vagnini VL, Kelly TH, Jiang Y. Sensation seeking predicts brain responses in the old-new task: converging multimodal neuroimaging evidence. Int J Psychophysiol. 2012 Jun;84(3):260-9. doi: 10.1016/j.ijpsycho.2012.03.003. Epub 2012 Apr 5. PubMed PMID: 22484516; PubMed Central PMCID: PMC3367102.

Joseph JE, Swearingen JE, Corbly CR, Curry TE Jr, Kelly TH. Influence of estradiol on functional brain organization for working memory. Neuroimage. 2012 Feb 1;59(3):2923-31. doi: 10.1016/j.neuroimage.2011.09.067. Epub 2011 Oct 1. PubMed PMID: 21985908; PubMed Central PMCID: PMC3392124.

Joseph JE, Gathers AD, Bhatt RS. Progressive and regressive developmental changes in neural substrates for face processing: testing specific predictions of the Interactive Specialization account. Dev Sci. 2011 Mar;14(2):227-41. doi: 10.1111/j.1467-7687.2010.00963.x. PubMed PMID: 21399706; PubMed Central PMCID: PMC3050484.

Perry JL, Joseph JE, Jiang Y, Zimmerman RS, Kelly TH, Darna M, Huettl P, Dwoskin LP, Bardo MT. Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. Brain Res Rev. 2011 Jan 1;65(2):124-49. doi: 10.1016/j.brainresrev.2010.09.001. Epub 2010 Sep 15. Review. PubMed PMID: 20837060; PubMed Central PMCID: PMC3005953

Harnish SM, Neils-Strunjas J, Eliassen J, Reilly J, Meinzer M, Clark JG, Joseph J. Visual discrimination predicts naming and semantic association accuracy in Alzheimer disease. Cogn Behav Neurol. 2010 Dec;23(4):231-9. doi: 10.1097/WNN.0b013e3181e61cf1. PubMed PMID: 21042208; PubMed Central PMCID: PMC3058303.

Pushkarskaya H, Liu X, Smithson M, Joseph JE. Beyond risk and ambiguity: deciding under ignorance. Cogn Affect Behav Neurosci. 2010 Sep;10(3):382-91. doi: 10.3758/CABN.10.3.382. PubMed PMID: 20805539.

Zieber N, Bhatt RS, Hayden A, Kangas A, Collins R, Bada H. Body Representation in the First Year of Life. Infancy. 2010 Sep;15(5):534-544. doi: 10.1111/j.1532-7078.2009.00026.x. Epub 2010 Jan 19. PubMed PMID: 32693509; PubMed Central PMCID: PMC7668307.

Bhatt RS, Hayden A, Kangas A, Zieber N, Joseph JE. Part perception in infancy: sensitivity to the short-cut rule. Atten Percept Psychophys. 2010 May;72(4):1070-8. doi: 10.3758/APP.72.4.1070. PubMed PMID: 20436201; PubMed Central PMCID: PMC7668309.

Jiang Y, Lianekhammy J, Lawson A, Guo C, Lynam D, Joseph JE, Gold BT, Kelly TH. Brain responses to repeated visual experience among low and high sensation seekers: role of boredom susceptibility. Psychiatry Res. 2009 Aug 30;173(2):100-6. doi: 10.1016/j.pscychresns.2008.09.012. Epub 2009 Jun 27. PubMed PMID: 19560906; PubMed Central PMCID: PMC2774088.

Hayden A, Bhatt RS, Zieber N, Kangas A. Race-based perceptual asymmetries underlying face processing in infancy. Psychon Bull Rev. 2009 Apr;16(2):270-5. doi: 10.3758/PBR.16.2.270. PubMed PMID: 19293093; PubMed Central PMCID: PMC7670847.

Joseph JE, Liu X, Jiang Y, Lynam D, Kelly TH. Neural correlates of emotional reactivity in sensation seeking. Psychol Sci. 2009 Feb;20(2):215-23. doi: 10.1111/j.1467-9280.2009.02283.x. PubMed PMID: 19222814; PubMed Central PMCID: PMC3150539.

Liu X, Steinmetz NA, Farley AB, Smith CD, Joseph JE. Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. J Cogn Neurosci. 2008 Sep;20(9):1711-26. doi: 10.1162/jocn.2008.20116. PubMed PMID: 18345986; PubMed Central PMCID: PMC2675283.

Martin SB, Covell DJ, Joseph JE, Chebrolu H, Smith CD, Kelly TH, Jiang Y, Gold BT. Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry. Neuropsychologia. 2007 Sep 20;45(12):2874-81. doi: 10.1016/j.neuropsychologia.2007.05.009. Epub 2007 May 26. PubMed PMID: 17603086; PubMed Central PMCID: PMC2971547.

Hayden A, Bhatt RS, Reed A, Corbly CR, Joseph JE. The development of expert face processing: are infants sensitive to normal differences in second-order relational information?. J Exp Child Psychol. 2007 Jun;97(2):85-98. doi: 10.1016/j.jecp.2007.01.004. Epub 2007 Mar 6. PubMed PMID: 17339043.

Liu X, Powell DK, Wang H, Gold BT, Corbly CR, Joseph JE. Functional dissociation in frontal and striatal areas for processing of positive and negative reward information. J Neurosci. 2007 Apr 25;27(17):4587-97. doi: 10.1523/JNEUROSCI.5227-06.2007. PubMed PMID: 17460071; PubMed Central PMCID: PMC6672982.

Joseph JE, Powell DK, Andersen AH, Bhatt RS, Dunlap MK, Foldes ST, Forman E, Hardy PA, Steinmetz NA, Zhang Z. fMRI in alert, behaving monkeys: an adaptation of the human infant familiarization novelty preference procedure. J Neurosci Methods. 2006 Oct 15;157(1):10-24. doi: 10.1016/j.jneumeth.2006.03.018. Epub 2006 May 3. PubMed PMID: 16675025.

Liu X, Wang H, Corbly CR, Zhang J, Joseph JE. The involvement of the inferior parietal cortex in the numerical Stroop effect and the distance effect in a two-digit number comparison task. J Cogn Neurosci. 2006 Sep;18(9):1518-30. doi: 10.1162/jocn.2006.18.9.1518. PubMed PMID: 16989552.

Joseph JE, Gathers AD, Liu X, Corbly CR, Whitaker SK, Bhatt RS. Neural developmental changes in processing inverted faces. Cogn Affect Behav Neurosci. 2006 Sep;6(3):223-35. doi: 10.3758/cabn.6.3.223. PubMed PMID: 17243358.

Joseph JE, Cerullo MA, Farley AB, Steinmetz NA, Mier CR. fMRI correlates of cortical specialization and generalization for letter processing. Neuroimage. 2006 Aug 15;32(2):806-20. doi: 10.1016/j.neuroimage.2006.04.175. Epub 2006 Jun 5. PubMed PMID: 16750396.

Bhatt RS, Hayden A, Reed A, Bertin E, Joseph J. Infants' perception of information along object boundaries: concavities versus convexities. J Exp Child Psychol. 2006 Jun;94(2):91-113. doi: 10.1016/j.jecp.2006.01.002. Epub 2006 Mar 3. PubMed PMID: 16516223.

Joseph JE, Farley AB. Cortical regions associated with different aspects of object recognition performance. Cogn Affect Behav Neurosci. 2004 Sep;4(3):364-78. doi: 10.3758/cabn.4.3.364. PubMed PMID: 15535172.

Gathers AD, Bhatt R, Corbly CR, Farley AB, Joseph JE. Developmental shifts in cortical loci for face and object recognition. Neuroreport. 2004 Jul 19;15(10):1549-53. doi: 10.1097/01.wnr.0000133299.84901.86. PubMed PMID: 15232281; PubMed Central PMCID: PMC4522001.

Joseph JE, Gathers AD, Piper GA. Shared and dissociated cortical regions for object and letter processing. Brain Res Cogn Brain Res. 2003 Jun;17(1):56-67. doi: 10.1016/s0926-6410(03)00080-6. PubMed PMID: 12763192.

Joseph JE, Gathers AD. Effects of structural similarity on neural substrates for object recognition. Cogn Affect Behav Neurosci. 2003 Mar;3(1):1-16. doi: 10.3758/cabn.3.1.1. PubMed PMID: 12822594.

Joseph JE, Partin DJ, Jones KM. Hypothesis testing for selective, differential, and conjoined brain activation. J Neurosci Methods. 2002 Aug 30;118(2):129-40. doi: 10.1016/s0165-0270(02)00122-x. PubMed PMID: 12204304.

Joseph JE, Gathers AD. Natural and manufactured objects activate the fusiform face area. Neuroreport. 2002 May 24;13(7):935-8. doi: 10.1097/00001756-200205240-00007. PubMed PMID: 12004194.

Joseph J, Noble K, Eden G. The neurobiological basis of reading. J Learn Disabil. 2001 Nov-Dec;34(6):566-79. doi: 10.1177/002221940103400609. PubMed PMID: 15503571.

Research Coverage in Popular Press:

APS Observer (J. Erwin, American Psychological Association). Theme Program: The Guide for Getting Risky, July/August, 2010.

CNBC (J. Weiss). Risk is in the Brain of the Beholder. October 10, 2011 (

New: Understanding our Need for Novelty and Change (W. Gallagher, Penguin Press), 2011 (research was cited).

National Post (A. Humphreys). The allure of risk: Are humans hard-wired to be drawn to death-defying stunts? June 9, 2012 (

Nautilus Magazine (J. MacKinnon). The strange brain of the world’s greatest solo climber. August 11, 2016. (

Business Insider (K. Loria). What the brain of a guy who climbs massive cliffs without ropes can teach us about fear. August 26. 2016. (

BYU Radio: Top of Mind with Julie Rose (interviewed about Alex Honnold’s brain scan). The Fearless Brain of Alex Honnold. June 21, 2017. ( 2cd5c69108f8?playhead=4576&autoplay=true)

New York Times (D. Duane). El Capitan, My El Capitan. June 9, 2017. (

Channel4 News (UK). (Interviewed about Alex Honnold’s brain scan). September 1, 2017:

WBEZ (Chicago): Nerdette. Feminism, Fear and Physics at the Winter Olympics. (interviewed about Alex Honnold’s brain scan). February 9, 2018:

National Geographic documentary film, “Free Solo” (E. Vasarhelyi & J. Chin, Directors). Released September 28 in US theaters. (appeared in film). Won Academy Award for Best Documentary Feature.

NPR: On Point (WBUR, Boston). ’Free Solo’ with death-defying rock climber Alex Honnold. October 9, 2018:

Wall Street Journal (R. Hooper). The Biology of Bravery. October 19, 2018:

MUSC Catalyst: The science of risk: How a neuroscientist and professional climber learned from one another. March 18, 2019:

The State newspaper (L. Daprile). PTSD, abuse may alter brain connectivity, but ‘love hormone’ could help, MUSC study finds. November 3, 2021:

BBC Radio: PM. (interviewed about free climbers’ brains). September 7, 2022: