Sambamurti Laboratory Publications

Huang M, Bargues-Carot A, Riaz Z, Wickham H, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease. Int J Mol Sci. 2022 Sep 16;23(18). doi: 10.3390/ijms231810808. Review. PubMed PMID: 36142718; PubMed Central PMCID: PMC9505762

Padhi P, Worth C, Zenitsky G, Jin H, Sambamurti K, Anantharam V, Kanthasamy A, Kanthasamy AG. Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders. Front Neurosci. 2022;16:836605. doi: 10.3389/fnins.2022.836605. eCollection 2022. Review. PubMed PMID: 35281490; PubMed Central PMCID: PMC8914070.

Cui J, Ait-Ghezala G, Sambamurti K, Gao F, Shen Y, Li R. Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease. J Neurosci. 2022 Feb 9;42(6):1154-1165. doi: 10.1523/JNEUROSCI.0864-20.2021. Epub 2021 Dec 13. PubMed PMID: 34903570; PubMed Central PMCID: PMC8824503.

Pappolla MA, Perry G, Fang X, Zagorski M, Sambamurti K, Poeggeler B. Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease. Neurobiol Dis. 2021 Aug;156:105403. doi: 10.1016/j.nbd.2021.105403. Epub 2021 Jun 1. Review. PubMed PMID: 34087380.

Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 Mar 2;10(1):81. doi: 10.1038/s41398-020-0757-2. PubMed PMID: 32123156; PubMed Central PMCID: PMC7052148.

Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 Feb 3;10(1):47. doi: 10.1038/s41398-020-0709-x. PubMed PMID: 32066688; PubMed Central PMCID: PMC7026402.

Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimers Dement (N Y). 2018;4:37-45. doi: 10.1016/j.trci.2017.12.001. eCollection 2018. PubMed PMID: 29955650; PubMed Central PMCID: PMC6021259.

Teich A, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini M. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2018 January; 4(1):37-45. doi: 10.1016/j.trci.2017.12.001.

Pappolla MA, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, Sambamurti K. Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis. Curr Alzheimer Res. 2018;15(7):637-642. doi: 10.2174/1567205015666180411092551. PubMed PMID: 29637859; PubMed Central PMCID: PMC8803126.

Lahiri DK, Maloney B, Sambamurti K. When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author. Gene. 2017 Nov 30;635:46-47. doi: 10.1016/j.gene.2017.08.011. Epub 2017 Sep 6. PubMed PMID: 28888578.

Lahiri D, Maloney B, Sambamurti K. When figures and data contradict text: MiR346 is apparently reduced in breast cancer tissue, contrary to claims by a paper's author. Gene. 2017 November; 635:46-47. doi: 10.1016/j.gene.2017.08.011.selectSambamurti, K.. Meet our editorial board member. Current Alzheimer Research. 2016; 13(3):213.

Zhao Y, Bhattacharjee S, Jones BM, Hill JM, Clement C, Sambamurti K, Dua P, Lukiw WJ. Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD). Mol Neurobiol. 2015 Aug;52(1):533-44. doi: 10.1007/s12035-014-8886-3. Epub 2014 Sep 10. Review. PubMed PMID: 25204496; PubMed Central PMCID: PMC4362880.

Baranello R, Bharani K, Padmaraju V, Chopra N, Lahiri D, Greig N, Pappolla M, Sambamurti K. Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease. Current Alzheimer Research. 2015 January; 12(1):32-46. doi: 10.2174/1567205012666141218140953.

Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015;12(1):32-46. doi: 10.2174/1567205012666141218140953. PubMed PMID: 25523424; PubMed Central PMCID: PMC4820400.

Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M. Resolution of inflammation is altered in Alzheimer's disease. Alzheimers Dement. 2015 Jan;11(1):40-50.e1-2. doi: 10.1016/j.jalz.2013.12.024. Epub 2014 Feb 12. PubMed PMID: 24530025; PubMed Central PMCID: PMC4275415.

Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald J, Serhan C, Granholm A, Schultzberg M. Resolution of inflammation is altered in Alzheimer's disease. Alzheimer's & Dementia. 2015 January; 11(1):40-50.e2. doi: 10.1016/j.jalz.2013.12.024.

Kindy, M.S., Akyol, \"O, Sambamurti, K.. Preface. Turkish journal of medical sciences. 2015; 45(5):i-ii.selectPappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice. Neurobiol Dis. 2014 Nov;71:215-9. doi: 10.1016/j.nbd.2014.07.012. Epub 2014 Aug 4. PubMed PMID: 25102344; PubMed Central PMCID: PMC5589075.

Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice. Neurobiology of Disease. 2014 November; 71:215-219. doi: 10.1016/j.nbd.2014.07.012.

Greig NH, Sambamurti K, Lahiri DK, Becker RE. Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment. Ann Neurol. 2014 Oct;76(4):629-30. doi: 10.1002/ana.24254. Epub 2014 Sep 5. PubMed PMID: 25146731; PubMed Central PMCID: PMC5179032.

Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein. PLoS One. 2014;9(3):e91531. doi: 10.1371/journal.pone.0091531. eCollection 2014. PubMed PMID: 24658363; PubMed Central PMCID: PMC3962361.

Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman C, Ramakrishnan V, Greig N, Pappolla M, Sambamurti K. Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein. PLoS ONE. 2014-3-; 9(3):e91531-. doi: 10.1371/journal.pone.0091531.

Greig NH, Tweedie D, Rachmany L, Li Y, Rubovitch V, Schreiber S, Chiang YH, Hoffer BJ, Miller J, Lahiri DK, Sambamurti K, Becker RE, Pick CG. Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimers Dement. 2014 Feb;10(1 Suppl):S62-75. doi: 10.1016/j.jalz.2013.12.011. PubMed PMID: 24529527; PubMed Central PMCID: PMC4201593.

Greig N, Tweedie D, Rachmany L, Li Y, Rubovitch V, Schreiber S, Chiang Y, Hoffer B, Miller J, Lahiri D, Sambamurti K, Becker R, Pick C. Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimer's & Dementia. 2014 February; 10:S62-S75. doi: 10.1016/j.jalz.2013.12.011.

Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May;21(5):474-83. doi: 10.1016/j.jagp.2013.02.009. PubMed PMID: 23570890; PubMed Central PMCID: PMC3740189.

Pinnix I, Ghiso J, Pappolla M, Sambamurti K. Major Carboxyl Terminal Fragments Generated by γ-Secretase Processing of the Alzheimer Amyloid Precursor Are 50 and 51 Amino Acids Long. The American Journal of Geriatric Psychiatry. 2013 May; 21(5):474-483. doi: 10.1016/j.jagp.2013.02.009.

Yu Q, Reale M, A. Kamal M, W. Holloway H, Luo W, Sambamurti K, Ray B, K. Lahiri D, T. Rogers J, H. Greig N. Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, α -Synuclein Synthesis, Interleukin-1β Release, and Cholinergic Action. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 2013 May; 12(2):117-128. doi: 10.2174/1871523011312020003.

Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 2013;12(2):117-28. doi: 10.2174/1871523011312020003. PubMed PMID: 23360256; PubMed Central PMCID: PMC5214460.

Vidal R, Sammeta N, Garringer HJ, Sambamurti K, Miravalle L, Lamb BT, Ghetti B. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. FASEB J. 2012 Jul;26(7):2899-910. doi: 10.1096/fj.12-205542. Epub 2012 Mar 29. PubMed PMID: 22459153; PubMed Central PMCID: PMC3382098.

Maloney B, Sambamurti K, Zawia N, Lahiri DK. Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. Curr Alzheimer Res. 2012 Jun;9(5):589-99. doi: 10.2174/156720512800617955. Review. PubMed PMID: 22300406.

Maloney B, Sambamurti K, Zawia N, K. Lahiri D. Applying Epigenetics to Alzheimer’s Disease via the Latent Early–life Associated Regulation (LEARn) Model. Current Alzheimer Research. 2012 May; 9(5):589-599. doi: 10.2174/156720512800617955.

Vidal R, Sammeta N, Garringer H, Sambamurti K, Miravalle L, Lamb B, Ghetti B. The <i>Psen1&#x2010;L166P</i> &#x2010;knock&#x2010;in mutation leads to amyloid deposition in human wild&#x2010;type amyloid precursor protein YAC transgenic mice. The FASEB Journal. 2012 March; 26(7):2899-2910. doi: 10.1096/fj.12-205542.

Ablonczy Z, Dahrouj M, Tang PH, Liu Y, Sambamurti K, Marmorstein AD, Crosson CE. Human retinal pigment epithelium cells as functional models for the RPE in vivo. Invest Ophthalmol Vis Sci. 2011 Nov 4;52(12):8614-20. doi: 10.1167/iovs.11-8021. PubMed PMID: 21960553; PubMed Central PMCID: PMC3208409.

Ablonczy Z, Dahrouj M, Tang P, Liu Y, Sambamurti K, Marmorstein A, Crosson C. Human Retinal Pigment Epithelium Cells as Functional Models for the RPE In Vivo. Investigative Opthalmology & Visual Science. 2011 November; 52(12):8614-. doi: 10.1167/iovs.11-8021.

Yu J, Gattoni-Celli M, Zhu H, Bhat N, Sambamurti K, Gattoni-Celli S, Kindy M. Vitamin D3-Enriched Diet Correlates with a Decrease of Amyloid Plaques in the Brain of A&#x3B2;PP Transgenic Mice. Journal of Alzheimer's Disease. 2011 July; 25(2):295-307. doi: 10.3233/JAD-2011-101986.

Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem. 2011 May;117(3):359-74. doi: 10.1111/j.1471-4159.2011.07213.x. Epub 2011 Mar 15. PubMed PMID: 21320126; PubMed Central PMCID: PMC3076515.

Sambamurti K, Greig N, Utsuki T, Barnwell E, Sharma E, Mazell C, Bhat N, Kindy M, Lahiri D, Pappolla M. Targets for AD treatment: conflicting messages from &#x3B3;-secretase inhibitors. Journal of Neurochemistry. 2011 May; 117(3):359-374. doi: 10.1111/j.1471-4159.2011.07213.x.

Britton G, Smith M, Perry G, Sambamurti K, Jagannatha Rao K. Drug Discovery for Neurodegenerative Diseases: Challenges and Novel Biochemical Targets. Journal of Alzheimer's Disease. 2011 April; 24(s2):1-2. doi: 10.3233/JAD-2011-110021.

Britton GB, Smith MA, Perry G, Sambamurti K, Jagannatha Rao KS. Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease. J Alzheimers Dis. 2011;24 Suppl 2:1-2. doi: 10.3233/JAD-2011-110021. PubMed PMID: 21525570.

Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. J Alzheimers Dis. 2011;25(2):295-307. doi: 10.3233/JAD-2011-101986. PubMed PMID: 21422528; PubMed Central PMCID: PMC5886011.

Prakasam A, Muthuswamy A, Ablonczy Z, Greig N, Fauq A, Rao K, Pappolla M, Sambamurti K. Differential Accumulation of Secreted A&#x3B2;PP Metabolites in Ocular Fluids. Journal of Alzheimer's Disease. 2010 June; 20(4):1243-1253. doi: 10.3233/JAD-2010-100210.

Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. PLoS One. 2010 Apr 21;5(4):e10206. doi: 10.1371/journal.pone.0010206. PubMed PMID: 20421998; PubMed Central PMCID: PMC2858081.

Poeggeler B, Sambamurti K, Siedlak S, Perry G, Smith M, Pappolla M. A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan. PLoS ONE. 2010-4-; 5(4):e10206-. doi: 10.1371/journal.pone.0010206.

Ramesh B, Rao T, Prakasam A, Sambamurti K, Rao K. Neuronutrition and Alzheimer's Disease. Journal of Alzheimer's Disease. 2010 March; 19(4):1123-1139. doi: 10.3233/JAD-2010-1312.

Li Y, Duffy K, Ottinger M, Ray B, Bailey J, Holloway H, Tweedie D, Perry T, Mattson M, Kapogiannis D, Sambamurti K, Lahiri D, Greig N. GLP-1 Receptor Stimulation Reduces Amyloid-&#x3B2; Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease. Journal of Alzheimer's Disease. 2010 March; 19(4):1205-1219. doi: 10.3233/JAD-2010-1314.

Zambón D, Quintana M, Mata P, Alonso R, Benavent J, Cruz-Sánchez F, Gich J, Pocoví M, Civeira F, Capurro S, Bachman D, Sambamurti K, Nicholas J, Pappolla MA. Higher incidence of mild cognitive impairment in familial hypercholesterolemia. Am J Med. 2010 Mar;123(3):267-74. doi: 10.1016/j.amjmed.2009.08.015. PubMed PMID: 20193836; PubMed Central PMCID: PMC2844655.

Zambón D, Quintana M, Mata P, Alonso R, Benavent J, Cruz-Sánchez F, Gich J, Pocoví M, Civeira F, Capurro S, Bachman D, Sambamurti K, Nicholas J, Pappolla M. Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia. The American Journal of Medicine. 2010 March; 123(3):267-274. doi: 10.1016/j.amjmed.2009.08.015.

Ramesh BN, Rao TS, Prakasam A, Sambamurti K, Rao KS. Neuronutrition and Alzheimer's disease. J Alzheimers Dis. 2010;19(4):1123-39. doi: 10.3233/JAD-2010-1312. Review. PubMed PMID: 20308778; PubMed Central PMCID: PMC2931824.

Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010;19(4):1205-19. doi: 10.3233/JAD-2010-1314. PubMed PMID: 20308787; PubMed Central PMCID: PMC2948479.

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