Smith Laboratory Publications

Smith ACW, Jonkman S, Difeliceantonio AG, O'Connor RM, Ghoshal S, Romano MF, Everitt BJ, Kenny PJ. Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions. Nat Commun. 2021 Aug 25;12(1):5121. doi: 10.1038/s41467-021-25460-3. PubMed PMID: 34433818; PubMed Central PMCID: PMC8387469.

Roberts-Wolfe DJ, Heinsbroek JA, Spencer SM, Bobadilla AC, Smith ACW, Gipson CD, Kalivas PW. Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking. Addict Biol. 2020 May;25(3):e12759. doi: 10.1111/adb.12759. Epub 2019 May 6. PubMed PMID: 31062493; PubMed Central PMCID: PMC7371007.

Lepack AE, Werner CT, Stewart AF, Fulton SL, Zhong P, Farrelly LA, Smith ACW, Ramakrishnan A, Lyu Y, Bastle RM, Martin JA, Mitra S, O'Connor RM, Wang ZJ, Molina H, Turecki G, Shen L, Yan Z, Calipari ES, Dietz DM, Kenny PJ, Maze I. Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science. 2020 Apr 10;368(6487):197-201. doi: 10.1126/science.aaw8806. PubMed PMID: 32273471; PubMed Central PMCID: PMC7228137.

Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC. Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking. Mol Neurobiol. 2020 Jan;57(1):346-357. doi: 10.1007/s12035-019-01711-9. Epub 2019 Jul 29. PubMed PMID: 31359322; PubMed Central PMCID: PMC6980501.

Calipari ES, Godino A, Salery M, Damez-Werno DM, Cahill ME, Werner CT, Gancarz AM, Peck EG, Jlayer Z, Rabkin J, Landry JA, Smith ACW, Defilippi P, Kenny PJ, Hurd YL, Neve RL, Dietz DM, Nestler EJ. Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration. J Neurosci. 2019 Jul 17;39(29):5634-5646. doi: 10.1523/JNEUROSCI.0024-19.2019. Epub 2019 May 15. PubMed PMID: 31092585; PubMed Central PMCID: PMC6636087.

Smith ACW, Kenny PJ. MicroRNAs regulate synaptic plasticity underlying drug addiction. Genes Brain Behav. 2018 Mar;17(3):e12424. doi: 10.1111/gbb.12424. Epub 2017 Oct 10. Review. PubMed PMID: 28873276; PubMed Central PMCID: PMC5837931.selectSmith ACW, Kenny PJ. HDAC5 Regulates the Formation of Drug Memories. Trends Mol Med. 2018 Feb;24(2):106-108. doi: 10.1016/j.molmed.2017.12.011. Epub 2018 Jan 25. PubMed PMID: 29396145.

Smith ACW. A Glitch in the Matrix: Aberrant Extracellular Matrix Proteolysis Contributes to Alcohol Seeking. Biol Psychiatry. 2017 Jun 1;81(11):900-902. doi: 10.1016/j.biopsych.2017.02.1181. PubMed PMID: 28502389; PubMed Central PMCID: PMC5742281.selectSmith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC 3rd, Boger HA, Kalivas PW. Accumbens nNOS Interneurons Regulate Cocaine Relapse. J Neurosci. 2017 Jan 25;37(4):742-756. doi: 10.1523/JNEUROSCI.2673-16.2016. PubMed PMID: 28123012; PubMed Central PMCID: PMC5296777.

Smith AC. Chromatin Remodeling in Addiction: BRG1-SMAD3 Interaction Contributes to Cued Reinstatement of Cocaine Seeking. Biol Psychiatry. 2016 Nov 1;80(9):e77-e78. doi: 10.1016/j.biopsych.2016.09.003. Epub 2016 Sep 7. PubMed PMID: 27697157; PubMed Central PMCID: PMC5453666.selectScofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW. The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. Pharmacol Rev. 2016 Jul;68(3):816-71. doi: 10.1124/pr.116.012484. Review. PubMed PMID: 27363441; PubMed Central PMCID: PMC4931870.

Smith AC, Scofield MD, Kalivas PW. The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. Brain Res. 2015 Dec 2;1628(Pt A):29-39. doi: 10.1016/j.brainres.2015.03.027. Epub 2015 Mar 30. Review. PubMed PMID: 25838241; PubMed Central PMCID: PMC4589426.

Smith AC, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, Kalivas PW. Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nat Neurosci. 2014 Dec;17(12):1655-7. doi: 10.1038/nn.3846. Epub 2014 Oct 19. PubMed PMID: 25326689; PubMed Central PMCID: PMC4241163.

Gipson CD, Reissner KJ, Kupchik YM, Smith AC, Stankeviciute N, Hensley-Simon ME, Kalivas PW. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9124-9. doi: 10.1073/pnas.1220591110. Epub 2013 May 13. PubMed PMID: 23671067; PubMed Central PMCID: PMC3670307.

Smith AW, Nealey KA, Wright JW, Walker BM. Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems. Neurobiol Learn Mem. 2011 Sep;96(2):199-206. doi: 10.1016/j.nlm.2011.04.011. Epub 2011 Apr 21. PubMed PMID: 21530666; PubMed Central PMCID: PMC3148339.

Nealey KA, Smith AW, Davis SM, Smith DG, Walker BM. κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology. 2011 Jul-Aug;61(1-2):35-42. doi: 10.1016/j.neuropharm.2011.02.012. Epub 2011 Feb 19. PubMed PMID: 21338616; PubMed Central PMCID: PMC3955175.

Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions. Nature communications. . NIHMSID: NIHMS1736922.