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The Jiang Lab

Photo of Dr. Wei Jiang 

Wei Jiang, M.D.

Associate Professor
Microbiology and Immunology

2018 - present, Associate Professor, Microbiology and Immunology; Medicine, Division of Infectious Diseases
2012 - 2018, Assistant Professor, Microbiology and Immunology; Medicine, Division of Infectious Diseases
2008 - 2012, Instructor, Infectious Diseases, Case Western Reserve University, Cleveland, OH
2002 - 2008, Research Associate, Infectious Diseases, Case Western Reserve University, Cleveland, OH

2008 MS, Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH
2001 MS, Immunology, Capital Medical University, Beijing, China
1997 MD, Internal Medicine, Capital Medical University, Beijing, China

Contact Info
Ashley Ave. BSB- 208D, Charleston, SC, 29425
Lab: 843-792-6310; Office: 843-876-2457

Research Interests
B cell dysfunction in HIV immunopathogenesis
Microbiome, systemic microbial translocation, and gut permeability
Immunopathogenesis of SLE diseases
Neuro-disorders and addictive drug abuse
Human translational clinical research using human blood, saliva, spinal fluid, and tissue samples.

Recent Publications
Luo Z, Wu Yx, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink M, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath S, Li Z, Alekseyenko A, Jiang W. Systemic translocation of Staphylococcus drives autoantibody production in HIV disease. Microbiome. 2019. Feb 14;7(1):25. doi: 10.1186/s40168-019-0646-1. PMID: 30764863

Luo Z, Ogunrinde E, Li M, Zhang L, Martin L, Zhou Z, Hu Z, Zhang T, Li Z, Zhang J, Su B, Zhang T, Wu H, Ma L, Liao G, Eckard AR, Westerink M, Heath S, Jiang W*. Increased influenza-specific antibody avidity in HIV-infected females compared to HIV-infected males on antiretroviral therapy. AIDS. 2018 Sep 17. doi: 10.1097/QAD.0000000000002022. PMID:30234599

Xu W, Luo Z, Alekseyenko A, Martin L, Wan Z, Ling B, Qin Z, Heath S, Maas K, Cong X, Jiang W*. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Sci. Rep. 2018. 8:12863 | DOI:10.1038/s41598-018-31116-y. PMID:30150778

Pan F, Tang W, Zhou Z, Gilkeson G, Lang R, Jiang W. Intestinal Macrophages in Mucosal Immunity and their role in Systemic Lupus Erythematosus Disease. Lupus. 2018 Oct;27(12):1898-1902. doi: 10.1177/0961203318797417. PMID:30223707

Zhou Z, Powell AM; Ramakrishnan V; Eckard A; Wagner C; Jiang W*. Elevated systemic microbial translocation in pregnant HIV-infected women compared to HIV-uninfected women, and its inverse correlations with plasma progesterone levels. J Reprod Immunol. 2018 Apr 10;127:16-18. doi: 10.1016/j.jri.2018.04.001. PMID: 29656181

Ou TW, Lilly M, Jiang W. The pathologic role of Toll-like receptor 4 in prostate cancer. Frontiers in Immunology. 2018 Jun 6;9:1188. doi: 10.3389/fimmu.2018.01188. PMID: 29928275
Jiang W*, Lisa Martin L, Wan Z, Fu P, Wagner A, Ling B, Heath S, Azizul H, McRae-Clark A. Drug use is associated with anti-CD4 IgG-mediated CD4+ T cell death and poor CD4+ T cell recovery in viral-suppressive HIV-infected individuals under antiretroviral therapy. Cur HIV Res. 2018 Jul 3. doi: 10.2174/1570162X16666180703151208. PMID:29968539.

Zhou Z, Guille C, Ogunrindea E, Liu R, Luo Z, Powell A, and Jiang W*. Increased systemic microbial translocation is associated with depression during early pregnancy. J Psychiatr Res. 2018; 97:54-57. PMID: 29179013; PMCID:PMC5742552

Jiang W*. A protocol for quantizing total bacterial 16S rDNA in plasma as a marker of microbial translocation in vivo. Nature Cellular and Molecular Immunology, 2018 Apr 16. Doi: 10.1038/cmi.2018.3. PMID: 29658510.

Zhou Z, Zhang L, Ding M, Luo Z, Yuan S, Bansal M, Gilkeson G, Lang R, Jiang W*. Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues. Clin Immunol. 2017 Sep 1;183:174-180. Doi: 10.1016/j.clim.2017.08.019. PMID: 28867253; PMCID:PMC5673541

Luo Z, Zhou Z, Ogunrinde E, Zhang T, Li Z, Martin L, Wan Z, Wu H, Qin Z, Ou T, Zhang J, Ma L, Liao G, Heath S, Huang L, Jiang W*. The effect of plasma auto-IgGs on CD4+ T cell apoptosis and recovery in HIV-infected patients under antiretroviral therapy. J Leuko Bio. 2017 Oct 13. doi: 10.1189/jlb.5A0617-219R. PMID:29030391

Luo Z, Li Z, Martin L, Wan Z, Meissner EG, Espinosa E, Wu H, Yu XC, Fu PF, Westerink MA, Kilby JM, Wu J, Huang L, Heath SL, Li ZH, Jiang W*. Pathological role of anti-CD4 antibodies in HIV-infected immunologic non-responders under viral suppressive antiretroviral therapy. J Infect Dis. 2017 Jul 1;216(1):82-91. doi: 10.1093/infdis/jix223. PMID:28498953; PMCID:PMC5853506

Luo Z, Ma L, Zhang L, Martin L, Wan Z, Warth S, Kilby A, Gao Y, Bhargava P, Meissner EG, Li Z, Kilby JM, Liao G, Jiang W*. Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination. Vaccine. 2016; 34(16): 945-55. PMCID: PMC4803607. PMID:26721328.

Zhou ZJ, Ding M, Huang L, Gilkeson G, Lang R, Jiang W*. Toll-like receptor-mediated immune responses in intestinal macrophages; implications for mucosal immunity and autoimmune diseases. Clin Immunol. 2016. Sep 9. pii: S1521-6616(16)30366-7. doi: 10.1016/j.clim.2016.09.005. PMID:27620642. PMCID:PMC5148676.

Powell AM, Luo Z, Martin L, Wan Z, Ma L, Liao G, Song Y, Li X, Kilby JM, Huang L, Jiang W*. The induction of CD80 and apoptosis on B cells and CD40L in CD4+ T cells in response to seasonal influenza vaccination distinguishes responders versus non-responders in healthy controls and aviremic ART-treated HIV-infected individuals. Vaccine. 2016. Dec22.pii:S0264-410X(16)31233-6.doi: 10.1016/j.vaccine.2016.12.026. PMID: 28017428. PMCID:PMC5253242.

Research Support

3R01AI128864-02S1 Jiang (PI) 08/10/18-4/30/21
B cell perturbation and anti-CD4 autoantibody production in HIV-infected immunologic non-responders
The purpose of the project is to investigate the B cell perturbation in immunologic non-responder HIV patients under viral-suppressive antiretroviral therapy in HIV disease.
Role on Project: PI

5R01 AI128864-01 Jiang (PI) 05/01/17-4/30/22
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV disease
The purpose of the project is to investigate the pathologic role of anti-CD4 antibodies in poor CD4+ T cell recovery after antiretroviral therapy in HIV disease.
Role on Project: PI

I01 CX001211 Gilkeson (PI) 10/01/18-09/30/22
The Role of Gut Microbial Translocation in Initiating Autoimmunity
The goals are to understand the mechanism of autoantibody production in SLE.
Role on Project: Co-I

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