Mulholland Laboratory Publications


Cannady, R., Nguyen, T., Padula, A.E., Rinker, J.A., Lopez, M.F., Becker, H.C., Woodward, J.J., Mulholland, P.J. (2021) Interaction of chronic intermittent ethanol and repeated stress on structural and functional plasticity in the mouse medial prefrontal cortex. Neuropharmacology, 182, 108396.

Padula, A.E., Rinker, J.A., Lopez, M.F., Mulligan, M.K., Williams, R.W., Becker, H.C., Mulholland, P.J. (2020) Bioinformatics identification and pharmacological validation of Kcnn3/KCa2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice. Translational Psychiatry, 10(1), 414.

Bloch, S., Rinker, J.A., Marcus, M.M., Mulholland, P.J. (2020) Absence of effects of intermittent access to alcohol on negative affective and anxiety-like behaviors in male and female C57BL/6J mice. Alcohol, 88, 91-99.

Cannady, R., Nimitvilai-Roberts, S., Jennings, S.D., Woodward, J.J., Mulholland, P.J. (2020) Distinct region- and time-dependent functional cortical adaptations in C57BL/6J mice after short and prolonged alcohol drinking. eNeuro, 19:7(3).

Smith, R. Anderson, R., Haun, H., Mulholland, P.J., Griffin, W.C., Lopez, M.F., Becker, H.C. (2019) Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking. Addiction Biology, 25(6):e12804.

McGuier, N.S., Rinker, J.A., Cannady, R., Fulmer, D.B., Jones, S.R., Hoffman, M., Mulholland, P.J. (2018) Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. Neuropharmacology, 138:10-19.

Cannady, R., McGonigal, J.T., Newson, R.J., Woodward, J.J., Mulholland, P.J.*, Gass, J.T.* (2017) Prefrontal cortex KCa2 channels regulate mGlu5-dependent plasticity and extinction of alcohol-seeking behavior. The Journal of Neuroscience, 37(16):4359-4369. *Co-Corresponding Authors.

Nimitvilai, S., Uys, J.D., Woodward, J.J., Randall, P.K., Ball, L.E., Williams, R.W., Jones, B.C., Lu, L., Grant, K.A., Mulholland, P.J. (2017) Orbitofrontal neuroadaptations and cross-species synaptic biomarkers in heavy drinking macaques. The Journal of Neuroscience, 37(13), 3646-3660.

Rinker, J.A., Fulmer, D.B., Trantham-Davidson, H., Smith, M.L., Williams, R.W., Lopez, M.F., Randall, P.K., Chandler, L.J., Miles, M.F., Becker, H.C., Mulholland, P.J. (2017) Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol, 58, 33-45.

McGuier, N.S., Griffin III, W.C., Gass, J.T., Padula, A.E., Chesler, E.J., Mulholland, P.J. (2016) KV7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addiction Biology.21(6), 1097-1112.

Uys, J.D., McGuier, N.S., Gass, J.T., Griffin III, W. C., Ball, L.E., Mulholland, P.J. (2016) Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addiction Biology, 21(3), 560-574.

Padula, A.E., Griffin III, W.C., Lopez, M.F., Nimitvilai, S., Cannady, R., McGuier, N.S., Chesler, E.J., Miles, M.F., Williams, R.W., Randall, P.K., Becker, H.C., Mulholland, P.J. (2015) KCNN genes that encode small-conductance Ca2+-activated K+ channels influence alcohol and drug addiction. Neuropsychopharmacology, 40(8), 1928-39.

McGuier, N.S., Padula, A.E., Mulholland, P.J., Chandler, L.J. (2015) Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing NMDA receptors in the nucleus accumbens. Frontiers in Pharmacology, 6:28.

Mulholland, P.J., Spencer, K.B., Hu, W., Kroener, S., Chandler, L.J. (2015) Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus. Psychopharmacology, 232(11), 1995-2006.

McGuier, N.S., Padula, A.E., Lopez, M.F., Woodward, J.J., Mulholland, P.J. (2015) Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. Alcohol, 49(1), 21-7.Mulholland, P.J., Becker, H.C., Woodward, J.J., Chandler, L.J. (2011) SK2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biological Psychiatry, 69(7), 625-632.

Mulholland, P.J., Carpenter-Hyland, E.P., Hearing, M.C., Becker, H.C., Woodward, J.J., Chandler, L.J. (2008) Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. The Journal of Neuroscience, 28(35), 8801-8809.

Review Articles & Book Chapters

Crews, F.T., Robinson, D.L., Chandler, L.J., Ehlers, C.L., Mulholland, P.J., Pandey, S.C., Rodd, Z.A., Spear, L.P., Swartzwelder, H.S., Vetreno, R.P. (2019) Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA Consortium findings. Alcoholism: Clinical and Experimental Research.

Rinker, J.A., Mulholland, P.J. (2017) Promising Pharmacogenetic Targets for Treating Alcohol Use Disorder: Evidence from Preclinical Models. Pharmacogenomics. 37(13), 3646-3660.

Mulholland, P.J., Chandler, L.J., Kalivas, P.W. (2016) Signals from the fourth dimension regulate drug relapse. Trends in Neurosciences. 39(7), 472-485.

Uys, J.D., Mulholland, P.J., Townsend, D.M. (2014) Glutathione and redox signaling in substance abuse. Biomedicine & Pharmacotherapy. 68(6), 799-807.

Becker, H.C., Mulholland, P.J. (2014) Neurochemical mechanisms of alcohol withdrawal. In E. Sullivan (Ed), Handbook of Clinical Neurology, 3rd series. Oxford, UK: Elsevier Ltd.

Padula, A.E., McGuier, N.S., Griffin III, W.C., Lopez, M.F., Becker, H.C., Mulholland, P.J. (2013) Novel anticonvulsants for reducing alcohol consumption: A review of evidence from preclinical rodent drinking models. OA Alcohol. 1(1), 2.

Prendergast, M.A., Mulholland, P.J. (2012) Glucocorticoid and polyamine interactions in the plasticity of glutamatergic synapses that contribute to ethanol-associated dependence and neuronal injury. Addiction Biology, 17(2), 209-223.

Mulholland, P.J. (2012) KCa2 channels: Novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. Alcohol, 46(4), 309-315.Mulholland, P.J., Hopf, F.W., Bukiya, A.N., Martin, G.E., Liu, J., Dopico, A.M. Bonci, A., Treistman, S.N., Chandler, L.J. (2009) Sizing up ethanol-induced plasticity: The role of small and large conductance calcium-activated potassium channels. Alcoholism: Clinical and Experimental Research, 33(7), 1125-1135.

Mulholland, P.J., Chandler, L.J. (2007) The thorny side of addiction: Adaptive plasticity and dendritic spines. TheScientificWorldJOURNAL. National Institute on Drug Abuse Special Issue on Frontiers in Addiction Research, 7(S2), 9-21.

Mulholland, P.J. (2006) Susceptibility of the cerebellum to thiamine deficiency. The Cerebellum, 5(1), 55-63.