Gregory A. Cote, M.D.

Gregory Cote, M.D. 

Associate Professor
Department: Medicine
Programs: Inflammation, Fibrosis, End Organ Disease



Research Interests:

Dr. Cote is a gastroenterologist with unique training in pancreatobiliary endoscopy, pancreatology, and clinical research methodology. Dr. Cote and his team are striving to identify the best management approaches for common inflammatory diseases of the pancreas, and have particular research interest in acute and chronic inflammatory disease of the pancreas – or the clinical entity, pancreatitis.

Dr. Cote’s experiences have centered around the development and execution of multicenter, randomized clinical trials. He has developed a national reputation in clinical and translational research related to pancreatobiliary endoscopy and pancreatology, including prior collaborations in the North American Pancreatitis Study 2, Study of Nutrition in Acute Pancreatitis, and his own K23- and R21-sponsored studies of indeterminate bile duct strictures (diagnostic testing, often seen in the setting of chronic pancreatitis) and benign bile duct strictures (optimal treatment, again often in the setting of chronic pancreatitis). Dr. Cote also has experience leading multicenter, randomized clinical trials in pancreatobiliary endoscopy, having chaired a multicenter (n=8) study comparing two endoscopic treatment approaches to benign bile duct strictures (this work was sponsored by the NIH research award R21 DK090708). The primary findings of this 112-subject randomized trial were published in JAMA.  Furthermore, Dr. Cote serves as the Co-PI for the Sphincterotomy for Acute Recurrent Pancreatitis with pancreas divisum (SHARP) clinical trial. This is an international, multicenter (n=17), sham-controlled study of minor papilla sphincterotomy for patients with recurrent acute pancreatitis and pancreas divisum which addresses a critical question in the field (this work is supported through the NIH cooperative agreement U01 DK116743). Finally, Dr. Cote serves as Co-PI for a longitudinal cohort study designed to measure outcomes of ERCP performed on subjects with sphincter of Oddi dysfunction and unexplained recurrent acute pancreatitis (this work is supported by the NIH research award R01 DK115495).


PubMed Collection