22nd ISRHML Agenda

Sunday, December 8, 2024

3:00pm *New* Pre-Conference Workshop "Human Milk Composition Data in Federal Nutrition Policy: Uses,
Limitations, and Future Directions"
National health and nutrition monitoring is a vital federal effort and often serves as the foundation for many
nutrition and health policies. Despite its importance, understanding child exposures through human milk
in population studies is hindered by a lack of current and representative data on human milk composition
and intake volumes. High-quality, comprehensive, and publicly available composition and essential metadata
could empower researchers and public health officials to assess infant and maternal nutritional needs
accurately, shaping public health policies, food and nutrition programs, and clinical practice guidelines
with the needed precision.

This complimentary workshop will adopt a co-learning, horizontal information-sharing approach. Participants
will engage with federal leaders in human milk composition, nutrition, and public health research and policy
to exchange ideas and discuss future visions.

Monday, December 9, 2024

8:00am Optional Workshop 1: Improving Human Milk and Breastfeeding Outcomes for Vulnerable Infants at
Discharge and Beyond, Dr. Diane Spatz
Overview: Most of the global attention to improve breastfeeding rates only focuses on the healthy term dyad. Mothers who have infants requiring intensive care face unique challenges This session will focus on 10 steps to improve human milk and breastfeeding with the associated research and outcomes associated.

10:00 Break

12:00pm Lunch (on your own)

1:00pm Optional Workshop 2: Human Milk and Lactation Research – Back to the Basics
Dr. Mark McGuire, Dr. Shelley McGuire, Dr. Paula Meier, Dr. Donna Geddes
Overview – Understanding mammary biology as a framework for developing appropriate sampling, laboratory methods, and analyses to study human milk and lactation.

2:30 Break

4:30 Workshop Adjourn

5:00 Welcome Reception

7:00 Reception Concludes

Tuesday, December 10, 2024

8:00am Welcome Address

8:30 Macy-Gyorgy Award Announcement and Recipient Lecture

10:00 Break - Discussions, Networking, Visit with Exhibitors

10:30 Session 1: New Discoveries in Immunologic Functions of Breast Milk,
Human milk antibodies in infectious diseases – do they really matter? A BMGF-funded project Dr. Kirsi Järvinen-Seppo

Human milk-derived immunoglobulin A reactivity against microbiota, Dr. Timothy Hand (virtual)

Maternal protection from enteric pathogens, Dr. Kathryn Knoop

Oral Abstract Presentations:

Alanna Slater: Immunomodulatory Effects of Human Milk Oligosaccharides on Immune Cells
Irma Castro Navarro: Immunological Profile of Human Milk Before and During Mastitis
Biana Bernshtein: IgA Antibodies in Breast Milk Protect Against Klebsiella Pneumoniae Colonization

12:00pm Lunch provided

1:00 Session 2: The Impact of Maternal Condition on Lactation, 
You can’t always pump your way out of low milk production: Evolving knowledge regarding maternal obesity, metabolic health and lactation outcomes, Dr. Laurie Nommsen-Rivers

Impact of Maternal Co-Morbidities in the Initiation of Lactation for Mothers of
Preterm Infants, Dr. Rebecca Hoban

Impact of maternal breast development, diet and diabetes on milk production
and composition, Dr. Donna Geddes

Oral Abstract Presentations:

Jayne Martin Carli: Obesity, Rather Than Insulin Resistance, Impairs Breastmilk Production During
        Early Lactation.
Marion Bendixon: The Influence of Maternal Health on Human Milk Biomarkers of Secretory
Activation in Pump-Dependent Mothers of Critically ill Infants
Mina Desai: Insulin Upregulates Mammary Milk and Lipid Synthesis: Use of 3-dimensional
Mammary Epithelial Cell Culture

2:45 Break - Discussions, Networking, Visit with Exhibitors 

3:00 Session 3: Findings from the International Milk Composition Consortium (IMiC): A Multidisciplinary
Approach to Studying Human Milk as a Biological System and Understanding its Relationship
with Infant Growth, Dr. Meghan Azad, IMiC Collaborators and Trainees

5:30 Session Concludes

5:45 Poster Symposium 1 (Non-CME)

Wednesday, December 11, 2024

8:00am Session 4: Human Milk as a Biological System
Introduction to the Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN) Project, Dr. Shelley McGuire

The Future of Human Milk Research at NIH, Dr. Andrew Bremer (virtual)

NIH-funded Awardee Presentations:
1. Milk-omics: Systems biology of human milk and its links to maternal and infant health, Dr. Ellen Demerath
2. Updates from the Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a Biological System and understand its composition, determinants, and impacts on child health, Dr. Meghan Azad
3. MOM2CHild Study: Leveraging systems biology toward discoveries in Maternal Obesity, Milk, and Translation to Child Health, Dr. Ardythe Morrow
4. Studying changes in milk with daily resolution: Lessons in high-frequency and home-based sampling, Dr. Bridget Young

10:00 Break - Discussions, Networking, Visit with Exhibitors

10:30 Session 5: Public Health Interventions and Economics of Breastfeeding Around the World,
What Makes Breastfeeding Work on a Large Scale: Lessons Learned Over Three Decades,
Dr. Rafael Pérez-Escamilla

  Public Health Interventions and Economics of Breastfeeding Around the World, Dr. Tricia Johnson

 Oral Abstract Presentations:

  Stephanie Marten: Acceptability of Strategies to Manage Informal Work and Exclusive
Breastfeeding Among Women in Moshi, Tanzania
Kimberly Mansen: Using a Human-centered Co-design Process in India, Malawi, and
Tanzania to Inform Development of a Lactation and Feeding Support 
Package for Preterm and Low-birthweight Newborns and Their Mothers 
Aleigha Mason: How Hospital Nursing Resources in the U.S Relate to Exclusive Breast
Milk Feeding Disparities in Hospitals Serving Black Mothers

12:00pm Lunch/TIG Professional Development Panel

1:30 Session 6: Genomics, Epigenetics and Transcriptomics of Human Milk,
Mapping epithelial cell functions during lactation using single-cell multiomic analysis, Dr. Brittany Goods

Oral Abstract Presentations:

  Janet Williams: Genome-wide Association Analysis of Fatty Acid Composition in
Human Milk: The INSPIRE Study
Sarah Nyquist: Integrated Omics Analysis Reveals Putative Shared and Unique
Gene Programs of HMO Production in the Human Mammary
Gland

Kelsey Johnson: Maternal Genetic and Dietary Influences on the Human Milk Metabolome

Yarden Golan: Genomic Characterization of Normal and Aberrant Human Milk Production

3:00 Break - Discussions, Networking, Visit with Exhibitors

3:30 Session 7: Breastfeeding and Chronic Disease Prevention,
Dr. Maureen Groer

Oral Abstract Presentations:

Ikuko Kato: Urinary Oxytocin Levels in One-Month-Old Infants Increase After
Breastfeeding

Courtney Meehan: Human Milk and Cannabis: The Lactation and Cannabis (LAC) Study

Melissa Manus: The Human Milk Microbiome Varies by Environmental Factors and
is Differentially Associated with Infant Growth: Findings from the
IMiC Study

Diane Taft: Exclusive Breastfeeding Reduces Infant Carriage of Antimicrobial
Resistant ESKAPE Pathogens as Part of the Gut Microbiome

Shannon Conrey:      Longer Duration of Breastfeeding Associated with Reduced
Healthcare Utilization but not Reduced Incidence of Acute
Respiratory Illness in Children Under 2 Years of Age
Rebecca Powell: Associations Between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach

5:00 Annual General Membership Meeting

6:00 Poster Session 2 (Non-CME)

Thursday, December 12, 2024

8:00am Session 8: The Mothers, Infants and Lactation Quality (MILQ) Study
Dr. Lindsay Allen, MILQ Collaborators and Trainees

10:30 Break - Discussions, Networking, Visit with Exhibitors

10:45 Session 9: Milk Bioactives, Microbiomes, and Maternal/Infant Health,                      
Mothers love to microbial magic: science of human milk and microbiota impact on infant immune system development, Dr. Laxmi Yeruva

Determinants of the assembly and function of the infant fecal microbiome in the STRONG kids 2 cohort, Dr. Sharon Donovan

Effect of donor milk processing on preservation of bioactive proteins, Dr. David Dallas

Oral Abstract Presentations:

  Lilian Lopez Leyva: Milk Mineral Composition is Strongly Associated with the
Milk Microbiota and Weakly with the Maternal Diet.
Viktorian Miok: A Systems Biology Analysis of Human Milk Oligosaccharides
Ryan Pace: Temporal and Ecological Dynamics of Bacterial Species in
Human Milk During the Early Postpartum Period
Lishi Deng: The Associations Between Maternal Milk Microbiome,
Oligosaccharides and Infant Gut Microbiota- Insights
from a Burkinabe Cohort Study

12:30pm Lunch/TIG Meet the Experts

1:30 Afternoon free to explore Charleston

6:00 ISRHML Gala Event (Dinner, Awards, Networking)

Friday, December 13, 2024

8:30am Session 10: Impact of Climate and Environment on Lactation
Dr. Dan Sellen, Elisabeth Cercero (Virtual) 

Oral Abstract Presentations:

  Nina Juntereal: Infant Feeding Practices: Environmental Implications
and Sustainable Strategies
Erin Davis: The Human Milk Metabolome Differs Among Women
Following Traditional Farming and Urban Lifestyles

9:30 TEP Bridge Trainee Award 

Oral Abstract Presentations:

  Jordyn Wallenborn: Human Milk and Infant Gut Microbiome and Fungi
Composition in a Low Income Country
Adwoa Gyamfi: Exploring Barriers and Opportunities for Community-
Based Lactation Support in Rural Ghana
Michael Pitino: High Pressure Processing and Holder Pasteurization
Differentially Impact Protein Digestion and Peptides
Released From Donor Human Milk Across Preterm
Infant in Vitro Digestion

10:00 Break - Discussions, Networking, Visit with Exhibitors

10:30 Session 11: Innovations in Breastfeeding Support
Telelactation on Breastfeeding by Race and Ethnicity: Results from a Randomized Trial in the United States, Dr. Jill Radtke Dermici

  Factors Associated with Tele-lactation Use and Lessons Learned, Dr. Azza H. Ahmed

Oral Abstract Presentations:

Ruth Lucas: Equitable Text-based Self-management Intervention to

Decrease Breast and Nipple Pain.

Lauren Keenan Devlin: Implementation of a Clinically Integrated Breastfeeding Peer Counselor Program to Address Income-based Disparities in Lactation Outcomes

11:30 Session 12: Hot Topics & Breaking Research

Oral Abstract Presentations:

Palika Datta: Determination of Semaglutide (Ozempic) in Human
Milk Following Subcutaneous Dosing
Michael Ross: Paired vs Alternate Breast Nursing: What is the
Difference in Milk Composition?
Clark Sims: While Unaffected by Maternal Activity During Pregnancy,
Human Milk 12,13-diHOME Levels are Associated with
Infant Adiposity at 2 and 6 months Postpartum Brigid Gregg: Validation of Methods to Preserve Human Milk RNA
Quality as Part of a Multi-site Cohort Study when Freezing
Samples Must Occur Before Extraction
Marieke de Sévaux: Human Milk Intake Across the Globe: A Compilation of
Data from the Deuterium Oxide Dose-To-Mother Technique
Aly Diana: Linking Human Milk Intake to Infant Linear Growth:
Insights from Sustainable Intervention of Supplementation
to Improve Kid's (SISTIK) Growth Study using Deuterium
Dose to Mother Technique

12:30pm Wrap-up Conference with Box Lunch, Dr. Carol Wagner

12:45 Adjourn

1:00 Optional Workshop 3: Communicating Lactation Science: Reflexive Engagement & Finding a
Path Forward (Offered in-person only), The public communication of lactation science faces a fraught media
landscape and social and political complexities. Workshop participants will have a chance to share the
challenges they encounter in their science communication efforts and engage reflexively in their own
SciComm practice. Participants will leave with an improved clarity on their own SciComm goals, tools for
engaging empathetically with the public, and a personal plan for next steps— both individual and collective.

4:30 Workshop concludes