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22nd ISRHML Agenda

Monday, December 9, 2024

8:00am Optional Workshop 1: Improving Human Milk and Breastfeeding Outcomes for Vulnerable Infants at
Discharge and Beyond
Overview: Most of the global attention to improve breastfeeding rates only focuses on the healthy term dyad. Mothers who have infants requiring intensive care face unique challenges This session will focus on 10 steps to improve human milk and breastfeeding with the associated research and outcomes associated.

? Helping Families Make Informed Decisions for Human Milk and Understanding the Science of Human
Milk as a Medical Intervention.

? Methods to Ensure Initiation and Maintenance of Milk Supply and Appropriate Human Milk Management.

10:00 Break

10:20 Oral Care with Human Milk and Initiation of Human Milk Feedings

? Non-Nutritive Suckling at the Breast and Transition to Direct Breastfeeding

? Measurement of Milk Transfer, Preparing for Discharge and Appropriate follow-up

12:00pm Lunch (on your own)

1:00pm Optional Workshop 2: Human Milk and Lactation Research – Back to the Basics
Overview – Understanding mammary biology as a framework for developing appropriate sampling, laboratory methods, and analyses to study human milk and lactation.

1:10 Mammary Gland Biology and Milk Synthesis

2:00 Why How Sampling and Measurement of Human Lactation Performance is Done Matters, Dr. Shelley McGuire

2:30 Break

2:50 Measuring Milk Production, Removal, and Infant Intake, Dr. Paula Meier

3:30 Collecting a Representative Milk Sample and Dose/Exposure to Infant

4:10 Panel Discussion

4:30 Workshop Adjourn

5:00 Welcome Reception

7:00 Reception Concludes

Tuesday, December 10, 2024

8:00am Welcome Address

8:30 Macy-Gyorgy Award Announcement and Recipient Lecture

10:00 Break - Discussions and Networking

10:30 Session 1: New Discoveries in Immunologic Functions of Breast Milk
Human milk antibodies in infectious diseases – do they really matter? Kirsi Järvinen-Seppo, MD, PhD Human milk-derived immunoglobulin A reactivity against microbiota, Timothy Hand, PhD (Virtual) Maternal protection from enteric pathogens, Kathryn Knoop, PhD Oral presentations based on abstracts

12:00pm Lunch provided

1:00 Session 2: The Impact of Maternal Condition on Lactation, Laurie Nommsen-Rivers, Donna Geddes, Rebekah Hoban
You can’t always pump your way out of low milk production: Evolving knowledge regarding maternal obesity, metabolic health and lactation outcomes, Laurie Nommsen-Rivers, PhD
Impact of Maternal Co-Morbidities in the Initiation of Lactation for Mothers of Preterm Infants, Rebecca Hoban, PhD
Donna Geddes
Oral presentations based on abstracts

3:00 Break - Discussions and Networking

3:30 Session 3: Findings from the International Milk Composition Consortium (IMiC): A Multidisciplinary Approach to Studying Human Milk as a Biological
System and Understanding its Relationship with Infant Growth
Part A - Overview + Integrated Multi-Omic Results IMiC: A multi-omics view of human milk composition across diverse geographies and environments Multi-omics methods in IMiC + Human milk composition in relation to maternal factors Human milk composition in relation to infant anthropometry Human milk composition following balanced energy protein or nicotinamide supplementation in three RCTs Part B - Single Omic Results Human Milk Metabolomics in IMiC Human Milk Microbiota in IMiC Colostrum in IMiC Part C - Learnings and applications Flash Talks from Poster Presenters: nutrients, proteomics, HMOs, targeted proteins LMIC Learnings from IMiC Panel Discussion: research, practice, policy and products

5:45 Poster Symposium 1

Wednesday, December 11, 2024

8:00am Session 4: Human Milk as a Biological System
Intro to BEGIN; Updates from NIH
NIH Funded Awardee Presentations: Dr. Ellen Demerath, Dr. Meghan Azad, Dr. Bridgette Young

10:00 Break - Discussions and Networking

10:30 Session 5: Public Health Interventions and Economics of Breastfeeding Around the World, Dr. Tricia Johnson, Rafael Pérez-Escamilla
Policy initiatives to promote breastfeeding, including maternity leave policies and workplace accommodations; Public health and healthcare system interventions to increase breastfeeding; Interventions to improve equity and inclusion in breastfeeding interventions; Economic evaluations of interventions to increase breastfeeding exclusivity and duration; Oral presentations based on abstracts

12:00pm Lunch/TIG Professional Development Panel

1:30 Session 6: Genomics, Epigenetics and Transcriptomics of Human Milk, Brittany Goods
Host genetic and epigenetic factors related to regulation of human milk composition; Transcriptomics of the mammary gland; Epigenetic studies examining how breastfeeding can influence gene expression and long-term health outcomes in offspring; The interplay between genetics, breastfeeding, and epigenetic modifications; Oral presentations based on abstracts

3:00 Break - Discussions and Networking

3:30 Session 7: Breastfeeding and Chronic Disease Prevention, Dr. Berthold Koletzko
What are the potential protective long-term effects of breastfeeding against chronic diseases such as obesity, diabetes, and cardiovascular diseases; Mechanisms through which breastfeeding may confer long-term health benefits; Later in Life: Life-expectancy of those who breastfeed, partially breastfeed vs. those who do not around the globe: is there a threshold in duration of
Oral presentations based on abstracts

5:00 Annual General Membership Meeting

6:00 Poster Session 2

Thursday, December 12, 2024

8:00am Session 8: The Mothers, Infants and Lactation Quality (MILQ) Study
Part A - Overview + Rationale: Reference Values for milk nutrients Why lactation research needs Reference Values Reference Values for milk Vitamins Reference Values for milk minerals Reference Values for milk vitamins Part B - Measurement Challenges Analytical Methods Practical Challenges Statistical Challenges Part C - Human Milk Composition: Determinants and Broader Insights Milk Volume and Micronutrient Status Maternal Diet and Micronutrient Status HMOs Microbiome Genome Part D: Panel Discussion: Research, practice, policy and products

10:30 Break - Discussions and Networking

10:45 Session 9: Maternal Impact on Short- and Long-term Infant Health
Studies on how human milk composition is associated with the development of the infant microbiomes (oral and gastrointestinal);
Differences between term and preterm infants;
Role of human milk oligosaccharides (HMOs) in shaping gut microbial composition and function;
Human milk proteins and peptides - potential impacts on infant health;
Oral presentations based on abstracts

12:00pm Lunch/Meet the Experts

1:00 Afternoon free to explore Charleston

6:00 ISRHML Gala Event (Dinner, Awards, Networking)

Friday, December 13, 2024

8:30am Session 10: Impact of Climate and Environment on Lactating Parent/Human Milk/Infant Triad
Impacts of climate on milk production and composition in dairy animals;
Positive effects of breastfeeding on climate;
Potential impact of climate and environment on lactation and milk composition in humans;
Oral presentations based on abstracts

10:00 Break - Discussions and Networking

10:30 Session 11: Innovations in Breastfeeding Support
Advances in breastfeeding technologies, such as wearable breast pumps and lactation apps;
Benefits and limitations of milk analyses in prescribing fortification for the preterm and high-risk infant with growth and developmental issues;
Telehealth and virtual lactation support services;
Oral presentations based on abstracts

 11:30 Session 12: Hot Topics & Breaking Research
Presentations chosen from abstracts reviewed by the Scientific Planning Committee

12:15pm Wrap-up Conference with Box Lunch, Carol Wagner, M.D.

12:45 Adjourn