ISRHML Abstracts

Pre-Conference Workshop "Human Milk Composition Data in Federal Nutrition Policy: Uses, Limitations, and Future Directions"

Improving Human Milk and Breastfeeding Outcomes for Vulnerable Infants at Discharge and Beyond
Dr. Diane Spatz

Human Milk and Lactation Research – Back to the Basics
Dr. Mark McGuire, Dr. Shelley McGuire, Dr. Paula Meier, Dr. Donna Geddes

Macy-Gyorgy Award Announcement and Recipient Lecture

Session 1: New Discoveries in Immunologic Functions of Breast Milk

1. Human milk antibodies in infectious diseases – do they really matter? A BMGF-funded project Dr. Kirsi Järvinen-Seppo
2. Human milk-derived immunoglobulin A reactivity against microbiota, Dr. Timothy Hand (virtual)
3. Maternal protection from enteric pathogens, Dr. Kathryn Knoop

 

Oral Abstract Presentations:

1. Alanna Slater: Immunomodulatory Effects of Human Milk Oligosaccharides on Immune Cells
2. Irma Castro Navarro: Immunological Profile of Human Milk Before and During Mastitis
3. Biana Bernshtein: IgA Antibodies in Breast Milk Protect Against Klebsiella Pneumoniae Colonization

Session 2: The Impact of Maternal Condition on Lactation

1. You can’t always pump your way out of low milk production: Evolving knowledge regarding Maternal obesity, metabolic health and lactation outcomes, Dr. Laurie Nommsen-Rivers
2. Impact of Maternal Co-Morbidities in the Initiation of Lactation for Mothers of Preterm Infants, Dr. Rebekah Hoban
3. Impact of maternal breast development, diet and diabetes on milk production and composition, Dr. Donna Geddes

 

Oral Abstract Presentations:

1. Jayne Martin Carli: Obesity, Rather Than Insulin Resistance, Impairs Breastmilk Production During Early Lactation.
2. Marion Bendixon: The Influence of Maternal Health on Human Milk Biomarkers of Secretory Activation in Pump-Dependent Mothers of Critically ill Infants
3. Mina Desai: Insulin Upregulates Mammary Milk and Lipid Synthesis: Use of 3-dimensional Mammary Epithelial Cell Culture

Session 3: Findings from the International Milk Composition Consortium (IMiC): A Multidisciplinary Approach to Studying Human Milk as a Biological System and Understanding its Relationship with Infant Growth
Dr. Meghan Azad, IMiC Collaborators and Trainees 

Session 4: Human Milk as a Biological System

1. Introduction to the Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN) Project, Dr. Shelley McGuire
2. The Future of Human Milk Research at NIH, Dr. Andrew Bremer (virtual)

                                               

NIH-funded Awardee Presentations:

1. Milk-omics: Systems biology of human milk and its links to maternal and infant health, Dr. Ellen Demerath
2. Updates from the Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a Biological System and understand its composition, determinants, and impacts on child health, Dr. Meghan Azad
3. MOM2CHild Study: Leveraging systems biology toward discoveries in Maternal Obesity, Milk, and Translation to Child Health, Dr. Ardythe Morrow            
4. Studying changes in milk with daily resolution: Lessons in high-frequency and home-based sampling, Dr. Bridget Young

Session 5: Public Health Interventions and Economics of Breastfeeding Around the World

1. What Makes Breastfeeding Work on a Large Scale: Lessons Learned Over Three Decades, Dr. Rafael Pérez-Escamilla                                               
2. Public Health Interventions and Economics of Breastfeeding Around the World, Dr. Tricia Johnson

Oral Abstract Presentations:

1. Stephanie Marten: Acceptability of Strategies to Manage Informal Work and Exclusive Breastfeeding Among Women in Moshi, Tanzania
2. Kimberly Mansen: Using a Human-centered Co-design Process in India, Malawi, and Tanzania to Inform Development of a Lactation and Feeding Support Package for Preterm and Low-birthweight Newborns and Their Mothers 
3. Aleigha Mason: How Hospital Nursing Resources in the U.S Relate to Exclusive Breast Milk Feeding Disparities in Hospitals Serving Black Mothers

Session 6: Genomics, Epigenetics and Transcriptomics of Human Milk

1. Mapping epithelial cell functions during lactation using single-cell multiomic analysis, Dr. Brittany Goods

Oral Abstract Presentations:

1. Janet Williams: Genome-wide Association Analysis of Fatty Acid Composition in Human Milk: The INSPIRE Study
2. Sarah Nyquist: Integrated Omics Analysis Reveals Putative Shared and Unique Gene Programs of HMO Production in the Human Mammary Gland
3. Kelsey Johnson: Maternal Genetic and Dietary Influences on the Human Milk Metabolome
4. Yarden Golan: Genomic Characterization of Normal and Aberrant Human Milk Production

Session 7: Breastfeeding and Chronic Disease Prevention
Dr. Maureen Groer

Oral Abstract Presentations:

1. Ikuko Kato: Urinary Oxytocin Levels in One-Month-Old Infants Increase After Breastfeeding
2. Courtney Meehan: Human Milk and Cannabis: The Lactation and Cannabis (LAC) Study
3. Melissa Manus: The Human Milk Microbiome Varies by Environmental Factors and is Differentially Associated with Infant Growth: Findings from the IMiC Study
4. Diane Taft: Exclusive Breastfeeding Reduces Infant Carriage of Antimicrobial Resistant ESKAPE Pathogens as Part of the Gut Microbiome
5. Shannon Conrey: Longer Duration of Breastfeeding Associated with Reduced Healthcare Utilization but not Reduced Incidence of Acute Respiratory Illness in Children Under 2 Years of Age
6. Rebecca Powell: Associations Between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach

Session 8: The Mothers, Infants and Lactation Quality (MILQ) Study
Dr. Lindsay Allen, MILQ Collaborators and Trainees

Session 9: Milk Bioactives, Microbiomes, and Maternal/Infant Health

1. Mothers love to microbial magic: science of human milk and microbiota impact on infant immune system development, Dr. Laxmi Yeruva
2. Determinants of the assembly and function of the infant fecal microbiome in the STRONG kids 2 cohort, Dr. Sharon Donovan
3. Effect of donor milk processing on preservation of bioactive proteins, Dr. David Dallas

 

Oral Abstract Presentations:

1. Lilian Lopez Leyva: Milk Mineral Composition is Strongly Associated with the Milk Microbiota and Weakly with the Maternal Diet.
2. Viktorian Miok: A Systems Biology Analysis of Human Milk Oligosaccharides
3. Ryan Pace: Temporal and Ecological Dynamics of Bacterial Species in  Human Milk During the Early Postpartum Period
4. Lishi Deng: The Associations Between Maternal Milk Microbiome, Oligosaccharides and Infant Gut Microbiota- Insights from a Burkinabe Cohort Study

Session 10: Impact of Climate and Environment on Lactation

1. ???, Dr. Dan Sellen
2. Breastfeeding and climate change, Elisabeth Cercero (Virtual) 

 

Oral Abstract Presentations:

1. Nina Juntereal: Infant Feeding Practices: Environmental Implications and Sustainable Strategies
2. Erin Davis: The Human Milk Metabolome Differs Among Women Following Traditional Farming and Urban Lifestyles

TEP Bridge Trainee Award

Oral Abstract Presentations:

1. Jordyn Wallenborn: Human Milk and Infant Gut Microbiome and Fungi Composition in a Low Income Country
2. Adwoa Gyamfi: Exploring Barriers and Opportunities for Community- Based Lactation Support in Rural Ghana
3. Michael Pitino: High Pressure Processing and Holder Pasteurization Differentially Impact Protein Digestion and Peptides Released From Donor Human Milk Across Preterm Infant in Vitro Digestion

Session 11: Innovations in Breastfeeding Support

1. Telelactation on Breastfeeding by Race and Ethnicity: Results from a Randomized Trial in the United States, Dr. Jill Radtke Dermici
2. Factors Associated with Tele-lactation Use and Lessons Learned, Dr. Azza H. Ahmed

 

Oral Abstract Presentations:

1. Ruth Lucas: Equitable Text-based Self-management Intervention to Decrease Breast and Nipple Pain.
2. Lauren Keenan Devlin: Implementation of a Clinically Integrated Breastfeeding Peer Counselor Program to Address Income-based Disparities in Lactation Outcomes

Session 12: Hot Topics & Breaking Research

 

Oral Abstract Presentations:                                     

1. Palika Datta: Determination of Semaglutide (Ozempic) in Human Milk Following Subcutaneous Dosing
2. Michael Ross: Paired vs Alternate Breast Nursing: What is the Difference in Milk Composition?
3. Clark Sims: While Unaffected by Maternal Activity During Pregnancy, Human Milk 12,13-diHOME Levels are Associated with Infant Adiposity at 2 and 6 months Postpartum
4. Brigid Gregg: Validation of Methods to Preserve Human Milk RNA Quality as Part of a Multi-site Cohort Study when Freezing Samples Must Occur Before Extraction
5. Marieke de Sévaux: Human Milk Intake Across the Globe: A Compilation of Data from the Deuterium Oxide Dose-To-Mother Technique
6. Aly Diana: Linking Human Milk Intake to Infant Linear Growth: Insights from Sustainable Intervention of Supplementation to Improve Kid's (SISTIK) Growth Study using Deuterium Dose to Mother Technique

Optional Workshop 3: Communicating Lactation Science: Reflexive Engagement & Finding a Path Forward