Research Projects

Our work focuses on improving the early detection of cognitive decline and Alzheimer's disease.

COVID-19 and Research Participation

We want to assure you that we are taking every precaution to keep our participants and study staff safe during this pandemic. This spring we put a pause on all study visits, and now we are working hard to transition back safely as we move forward.

We have instituted a few changes to our study procedures. We will now be able to do some procedures remotely, either by phone or video. This will limit face-to-face time and participant time spent on campus at MUSC.

Although it is not possible to complete all study procedures remotely, you may rest assured that your safety is our top priority. We are disinfecting surfaces frequently, limiting clinic capacities to allow for social distancing, and using protective equipment like gloves and masks.

COVID modifications for testing           COVID modifications for MRI

IAM Study

IAM Study logo 

Although the single most significant risk factor for developing Alzheimer's disease (AD) is age, the mechanisms underlying the transition from normal aging to AD are not well understood. One hypothesized mechanism for this transition is the loss of white matter (WM) integrity. The overall hypothesis of this project is that an accelerated loss of WM integrity is evident in the transition from normal aging to AD, and by combining biomarkers of WM integrity, degree of Aβ accumulation, neurodegeneration, and cognitive function, we will be able to stratify cognitively intact older adults for risk of conversion to AD.

Procedures: Participants will have two study visits (about 2 years apart) where they will undergo memory testing, blood draw, brain MRI and PET scan. At the second visit, participants will repeat the memory testing and brain MRI. Participants are required to have a Co-Participant. This individual must be a reliable informant that has contact with the participant at least once per week.

Funding: NIH / National Institute on Aging R01AG054159 (2017-2022). Link to our NIH project page.

Contact: Katrina Madden 843-792-9186