This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance, and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. We have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation, and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors, and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise.
This project is funded by the National Institute of General Medical Sciences.
Quantitative Assessment of PubMed Search of glutathionylation papers.
The spreadsheet lists those papers that gave positive hits for the terms thiolation or glutathionylation. The protein clusters list essential characteristics of the protein subject matter of each paper. In some instances, multiple proteins are represented. In others, there is no cluster represented. The pi diagram provides a rough proportional estimate of the protein cluster foci of the papers, but because there is repetition, does not give an accurate count of the total proteins represented.
| Clusters are roughly collected as:
(1) Structural proteins including channel and transporter functions
(2) Energy metabolism, particularly those in mitochondria
(3) Signal transduction and transcription factors
(4) Proteins involved in redox homeostasis
(5) Protein folding, chaperone functions
(6) Kinases and phosphatases
(7) Enzymes in intermediate metabolism, thiol active centers and calcium homeostasis
(8) Proteins influencing cell survival/death (e.g. caspases)
|Protein Citations Spreadsheet