IAM Study

IAM Study logo

Although the single most significant risk factor for developing Alzheimer's disease (AD) is age, the mechanisms underlying the transition from normal aging to AD are not well understood. One hypothesized mechanism for this transition is the loss of white matter (WM) integrity. The overall hypothesis of this project is that an accelerated loss of WM integrity is evident in the transition from normal aging to AD, and by combining biomarkers of WM integrity, degree of Aβ accumulation, neurodegeneration, and cognitive function, we will be able to stratify cognitively intact older adults for risk of conversion to AD.

Procedures: Participants will have two study visits (about 2 years apart) where they will undergo memory testing, blood draw, brain MRI and PET scan. At the second visit, participants will repeat the memory testing and brain MRI. Participants are required to have a Co-Participant. This individual must be a reliable informant that has contact with the participant at least once per week.

Funding: NIH / National Institute on Aging R01AG054159 (2017-2022). Link to our NIH project page. (2023-2028). Link to our NIH project page.

Contact: Katrina Madden 843-792-9186 IAMstudy@musc.edu.

Link to our IAM publications.

Check out an episode of the Health Focus podcast in which Dr. Christine Cooper talks about research suggesting that certain healthy lifestyle choices can help reduce the risk of dementia. Click here to listen.