COBRE Members

Principal Investigator

Kenneth D. Tew, Ph.D., DSc
Chair & Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
John C. West Chair in Cancer Research

Investigators

Lalima Ahuja

Lalima G. Ahuja, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Protein-Phosphorylation based Signaling

 

Peggi Angel, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Systems-based analysis of redox activity in aortic valve stenosis

 

Seok-hyung Kim, Ph.D.
Assistant Professor
College of Medicine
Mitochondrial Disease Associated Mutations as novel Genetic Risk Factors to Develop Advanced Fatty Liver Disease

 

Gavin Wang, M.D., Ph.D.
Assistant Professor
Pathology and Laboratory Medicine
Targeting Cancer Stem Cells for Breast Cancer Treatment

 

Haizhen Wang, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Targeting CDK6 for T-cell acute lymphoblastic leukemia (T-ALL) therapy

Pilot Projects

Kyu-Ho Lee, M.D., Ph.D.
Assistant Professor
Department of Pediatrics
The novel iron sulfur-targeting protein Ccdc117 plays a regulatory role in bioenergetics metabolism

Mehrotra
Shikhar Mehrotra, Ph.D.
Associate Professor
Department of Surgery
Factors that shape T cell immune response

Mehrotra
Jessica Thaxton, Ph.D.
Assistant Professor
Orthopaedics and Physical Medicine
PERK deficient T cells possess substantial spare respiratory capacity and control tumor growth relative to controls

 

Core Directors

 


Danyelle Townsend, Ph.D.
Director
Analytical Redox Biology Core

 


John Lemasters, Ph.D.
Director
Cell and Molecular Imaging Core

 


Lauren Ball, Ph.D.
Director
Proteomics CorePilot Projects

Mentors

Richard R. Drake, Jr., Ph.D.
Professor
Cell and Molecular Pharmacology and Experimental Therapeutics

 

Scott T. Eblen, Ph.D.
Associate Professor
Cell and Molecular Pharmacology and Experimental Therapeutics

 

Anand Mehta, DPhil
Professor
Cell and Molecular Pharmacology and Experimental Therapeutics

 

Kenneth D. Tew, Ph.D., DSc
Chair & Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
John C. West Chair in Cancer Research

 

Danyelle Townsend, Ph.D.
Associate Professor
Drug Discovery and Biomedical Sciences

Administrative Staff

Deza Finn
Administrative Manager

Thomas Kolette
Administrative Coordinator

Carly Lauer
Grants Coordinator

Caitlin Myers Hernandez
Administrative Coordinator

Graduates

Sherine Chan, Ph.D.
Associate Professor
Drug Discovery and Biomedical Sciences

 

James Chou, Ph.D.
Associate Professor
Drug Discovery and Biomedical Sciences
Awarded RO1: Novel lysine deacetylase 6 Hsp domain inhibitors against AML (1R01CA163452-01A1)

 

Eduardo Maldonado, DVM, Ph.D.
Assistant Professor
Drug Discovery and Biomedical Sciences
Awarded RO1: VDAC Opening Small Molecules to Revert Warburg Metabolism and Induce Oxidative Stress

 

Mariana Pehar, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Awarded R01: NGF and RAGE-p75NTR signaling in models of amyotrophic lateral sclerosis

 

Danyelle Townsend, Ph.D.
Associate Professor
Drug Discovery and Biomedical Sciences

 

Joachim Uys, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Awarded R01: GSTP-Mediated Redox Protein Signaling and Binge-line Ethanol Drinking

 

Marcelo Vargas, Ph.D.
Assistant Professor
Cell and Molecular Pharmacology and Experimental Therapeutics
Awarded RO1: NAD metabolism and mitochondrial dysfunction in ALS models (R01NS089640)

COBRE Internal Advisory Board

Kathleen T. Brady, M.D., Ph.D.
Distinguished University Professor
Associate Dean for Clinical Research

Alan Diehl, Ph.D.
Professor of Biochemistry and Molecular Biology
Endowed Chair Lipidomics & Pathology

Phil Howe, Ph.D.
Professor
Biochemistry and Molecular Biology
Endowed Chair for Clinical Oncology

Keith Kirkwood, D.D.S., Ph.D.
Professor
Associate Dean of Research
College of Dental Medicine

Igor Roninson, Ph.D.
Professor
SCCP Pharmaceutical and Biomedical Sciences -USC Campus

COBRE External Advisory Board

Kenneth D. Tew, Ph.D., DSc
Medical University of South Carolina

 

Franklin G. Berger, Ph.D.
University of South Carolina

 

Yvonne Janssen-Heininger, Ph.D.
The University of Vermont

 

Dean P. Jones, Ph.D.
Emory University of Medicine

 

Garth Powis, D. Phil
Sanford Burnham Prebys Medical Discovery Institute

 

Peter J. van Bladeren, Ph.D.
Nestlé: Retired Vice President of Regulatory & Scientific Affairs